Human PTEN/10q23del/BZS ORF/cDNA clone-Adenovirus particle (NM_000314)

Cat. No.: vGMAP-SPh-143

Pre-made Human PTEN/10q23del/BZS Adenovirus for PTEN overexpression in-vitro and in-vivo. The PTEN adenoviral vector excels as a vehicle for transient gene transfection in both stable cell lines and primary cells, including DC cells, macrophages, cardiomyocytes, hepatocytes, and neurons. The purified PTEN-encoding adenovirus also stands out as a quintessential tool for in vivo studies and vaccine research initiatives.

At GM Vector Core (GMVC), we provide bespoke adenovirus development and manufacture various grades of adenoviruses utilizing cutting-edge techniques. Dive deeper into our offerings.

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Adenovirus Grade Adenovirus quantity
vGMAP-SPh-143 Human PTEN Adenovirus particle Research Grade-In vitro 1E+10PFU (1E+10pfu/ml×1ml)
5E+10PFU (1E+10pfu/ml×5ml)
1E+11PFU (1E+10pfu/ml×10ml)
Research Grade-In vivo 1E+11PFU (1E+11pfu/ml×1ml)
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMAP-SPh-143
Gene Name PTEN
Accession Number NM_000314
Gene ID 5728
Species Human
Product Type Adenovirus particle (overexpression)
Insert Length 1212 bp
Gene Alias 10q23del,BZS,CWS1,DEC,GLM2,MHAM,MMAC1,PTEN1,PTENbeta,TEP1
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T38257-Ab Anti-PTEN/ 10q23del/ BZS monoclonal antibody
    Target Antigen GM-Tg-g-T38257-Ag PTEN VLP (virus-like particle)
    ORF Viral Vector pGMLP005649 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMLV000452 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMLV001225 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMLV002290 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMAD000006 Human PTEN Adenovirus plasmid
    ORF Viral Vector pGMLP-SPh-003 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-143 Human PTEN Adenovirus plasmid
    ORF Viral Vector pGMPC000358 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001526 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001692 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC004795 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP005649 Human PTEN Lentivirus particle
    ORF Viral Vector vGMLV000452 Human PTEN Lentivirus particle
    ORF Viral Vector vGMLV001225 Human PTEN Lentivirus particle
    ORF Viral Vector vGMLV002290 Human PTEN Lentivirus particle
    ORF Viral Vector vGMAD000006 Human PTEN Adenovirus particle
    ORF Viral Vector vGMLP-SPh-003 Human PTEN Lentivirus particle
    ORF Viral Vector vGMAP-SPh-143 Human PTEN Adenovirus particle


    Target information

    Target ID GM-T38257
    Target Name PTEN
    Gene ID 5728, 19211, 705121, 50557, 101091813, 403832, 540786, 100062388
    Gene Symbol and Synonyms 10q23del,2310035O07Rik,A130070J02Rik,B430203M17Rik,BZS,CWS1,DEC,GLM2,MHAM,Mmac,MMAC1,PTEN,PTEN1,PTENbeta,TEP1
    Uniprot Accession P60484
    Uniprot Entry Name PTEN_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000171862
    Target Classification Tumor-associated antigen (TAA)

    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]



    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.