Human TTR/HsT2651/TBPA ORF/cDNA clone-Adenovirus particle (BC005310)

Cat. No.: vGMAP000187

Pre-made Human TTR/HsT2651/TBPA Adenovirus for TTR overexpression in-vitro and in-vivo. The TTR adenoviral vector excels as a vehicle for transient gene transfection in both stable cell lines and primary cells, including DC cells, macrophages, cardiomyocytes, hepatocytes, and neurons. The purified TTR-encoding adenovirus also stands out as a quintessential tool for in vivo studies and vaccine research initiatives.

At GM Vector Core (GMVC), we provide bespoke adenovirus development and manufacture various grades of adenoviruses utilizing cutting-edge techniques. Dive deeper into our offerings.

Target products collection

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Adenovirus Grade Adenovirus quantity
vGMAP000187 Human TTR Adenovirus particle Research Grade-In vitro 1E+10PFU (1E+10pfu/ml×1ml)
5E+10PFU (1E+10pfu/ml×5ml)
1E+11PFU (1E+10pfu/ml×10ml)
Research Grade-In vivo 1E+11PFU (1E+11pfu/ml×1ml)
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMAP000187
Gene Name TTR
Accession Number BC005310
Gene ID 7276
Species Human
Product Type Adenovirus particle (overexpression)
Insert Length 444 bp
Gene Alias HsT2651,TBPA
Fluorescent Reporter GFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Kanamycin
ORF Nucleotide Sequence ATGGCTTCTCATCGTCTGCTCCTCCTCTGCCTTGCTGGACTGGTATTTGTGTCTGAGGCTGGCCCTACGGGCACCGGTGAATCCAAGTGTCCTCTGATGGTCAAAGTTCTAGATGCTGTCCGAGGCAGTCCTGCCATCAATGTGGCCGTGCATGTGTTCAGAAAGGCTGCTGATGACACCTGGGAGCCATTTGCCTCTGGGAAAACCAGTGAGTCTGGAGAGCTGCATGGGCTCACAACTGAGGAGGAATTTGTAGAAGGGATATACAAAGTGGAAATAGACACCAAATCTTACTGGAAGGCACTTGGCATCTCCCCATTCCATGAGCATGCAGAGGTGGTATTCACAGCCAACGACTCCGGCCCCCGCCGCTACACCATTGCCGCCCTGCTGAGCCCCTACTCCTATTCCACCACGGCTGTCGTCACCAATCCCAAGGAATGA
ORF Protein Sequence MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T86462-Ab Anti-TTHY/ TTR/ ATTR functional antibody
    Target Antigen GM-Tg-g-T86462-Ag TTR protein
    ORF Viral Vector pGMLP000332 Human TTR Lentivirus plasmid
    ORF Viral Vector pGMLP002013 Human TTR Lentivirus plasmid
    ORF Viral Vector pGMAP000187 Human TTR Adenovirus plasmid
    ORF Viral Vector pGMPC001668 Human TTR Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP000332 Human TTR Lentivirus particle
    ORF Viral Vector vGMLP002013 Human TTR Lentivirus particle
    ORF Viral Vector vGMAP000187 Human TTR Adenovirus particle


    Target information

    Target ID GM-T86462
    Target Name TTR
    Gene ID 7276, 22139, 705943, 24856, 101085927, 480167, 280948, 100052147
    Gene Symbol and Synonyms ATTR,CTS,CTS1,HEL111,HsT2651,Lr1,PALB,prealbumin,TBPA,TT,TTN,TTR,TTR1
    Uniprot Accession P02766
    Uniprot Entry Name TTHY_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease Ovary Cancer, hepatitis B, ovarian cancer, Ovarian Cancer, Diabetic Nephropathy, Alzheimer's Disease, Choroid plexus tumors, Dent disease, IgA glomerulonephritis, Nephrotic syndrome with focal and segmental glomerular lesions, Type 2 diabetes mellitus
    Gene Ensembl ENSG00000118271
    Target Classification Not Available

    This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]



    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.