Human TTR/ATTR/CTS ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_000371)

Cat. No.: pGMPC001668
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human TTR/ATTR/CTS Non-Viral expression plasmid (overexpression vector) for mouse TTR overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC001668
Gene Name TTR
Accession Number NM_000371
Gene ID 7276
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 444 bp
Gene Alias ATTR,CTS,CTS1,HEL111,HsT2651,PALB,TBPA,TTN
Fluorescent Reporter Null
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGCTTCTCATCGTCTGCTCCTCCTCTGCCTTGCTGGACTGGTATTTGTGTCTGAGGCTGGCCCTACGGGCACCGGTGAATCCAAGTGTCCTCTGATGGTCAAAGTTCTAGATGCTGTCCGAGGCAGTCCTGCCATCAATGTGGCCGTGCATGTGTTCAGAAAGGCTGCTGATGACACCTGGGAGCCATTTGCCTCTGGGAAAACCAGTGAGTCTGGAGAGCTGCATGGGCTCACAACTGAGGAGGAATTTGTAGAAGGGATATACAAAGTGGAAATAGACACCAAATCTTACTGGAAGGCACTTGGCATCTCCCCATTCCATGAGCATGCAGAGGTGGTATTCACAGCCAACGACTCCGGCCCCCGCCGCTACACCATTGCCGCCCTGCTGAGCCCCTACTCCTATTCCACCACGGCTGTCGTCACCAATCCCAAGGAATGA
ORF Protein Sequence MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T86462-Ab Anti-TTHY/ TTR/ ATTR functional antibody
    Target Antigen GM-Tg-g-T86462-Ag TTR protein
    ORF Viral Vector pGMLP000332 Human TTR Lentivirus plasmid
    ORF Viral Vector pGMLP002013 Human TTR Lentivirus plasmid
    ORF Viral Vector pGMAP000187 Human TTR Adenovirus plasmid
    ORF Viral Vector pGMPC001668 Human TTR Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP000332 Human TTR Lentivirus particle
    ORF Viral Vector vGMLP002013 Human TTR Lentivirus particle
    ORF Viral Vector vGMAP000187 Human TTR Adenovirus particle


    Target information

    Target ID GM-T86462
    Target Name TTR
    Gene ID 7276, 22139, 705943, 24856, 101085927, 480167, 280948, 100052147
    Gene Symbol and Synonyms ATTR,CTS,CTS1,HEL111,HsT2651,Lr1,PALB,prealbumin,TBPA,TT,TTN,TTR,TTR1
    Uniprot Accession P02766
    Uniprot Entry Name TTHY_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease Ovary Cancer, hepatitis B, ovarian cancer, Ovarian Cancer, Diabetic Nephropathy, Alzheimer's Disease, Choroid plexus tumors, Dent disease, IgA glomerulonephritis, Nephrotic syndrome with focal and segmental glomerular lesions, Type 2 diabetes mellitus
    Gene Ensembl ENSG00000118271
    Target Classification Not Available

    This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]



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