Human ITCH/ADMFD/AIF4 ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_001257137.3)

Cat. No.: pGMPC001096
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human ITCH/ADMFD/AIF4 Non-Viral expression plasmid (overexpression vector) for mouse ITCH overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC001096
Gene Name ITCH
Accession Number NM_001257137.3
Gene ID 83737
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 2712 bp
Gene Alias ADMFD,AIF4,AIP4,NAPP1
Fluorescent Reporter Null
Mammalian Cell Selection Null
Fusion Tag HA (C-Terminal)
Promoter CMV
Resistance Amplicin

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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T81240-Ab Anti-ITCH monoclonal antibody
    Target Antigen GM-Tg-g-T81240-Ag ITCH protein
    ORF Viral Vector pGMLV000051 Human ITCH Lentivirus plasmid
    ORF Viral Vector pGMAD001304 Human ITCH Adenovirus plasmid
    ORF Viral Vector pGMPC001096 Human ITCH Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV000051 Human ITCH Lentivirus particle
    ORF Viral Vector vGMAD001304 Human ITCH Adenovirus particle


    Target information

    Target ID GM-T81240
    Target Name ITCH
    Gene ID 83737, 16396, 707640, 311567, 101086133, 477199, 508431, 100069340
    Gene Symbol and Synonyms 6720481N21Rik,8030492O04Rik,A130065M08,ADMFD,AIF4,AIP4,C230047C07Rik,ITCH,NAPP1
    Uniprot Accession Q96J02
    Uniprot Entry Name ITCH_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000078747
    Target Classification Tumor-associated antigen (TAA)

    This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]



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