Human ADRB2/ADRB2R/ADRBR ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_000024.6)

SKU: pGMPC000618
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human ADRB2/ADRB2R/ADRBR Non-Viral expression plasmid (overexpression vector) for mouse ADRB2 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC000618
Gene Name ADRB2
Accession Number NM_000024.6
Gene ID 154
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 1242 bp
Gene Alias ADRB2R,ADRBR,B2AR,BAR,BETA2AR
Fluorescent Reporter Null
Mammalian Cell Selection Null
Fusion Tag Null
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T52522-Ab Anti-ADRB2/ ADRB2R/ ADRBR monoclonal antibody
    Target Antigen GM-Tg-g-T52522-Ag ADRB2 VLP (virus-like particle)
    ORF Viral Vector pGMLP003663 Human ADRB2 Lentivirus plasmid
    ORF Viral Vector pGMLV000869 Human ADRB2 Lentivirus plasmid
    ORF Viral Vector pGMPC000618 Human ADRB2 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP003663 Human ADRB2 Lentivirus particle
    ORF Viral Vector vGMLV000869 Human ADRB2 Lentivirus particle


    Target information

    Target ID GM-T52522
    Target Name ADRB2
    Gene ID 154, 11555, 710146, 24176, 493767, 403910, 281605, 100060659
    Gene Symbol and Synonyms Adrb-2,ADRB2,ADRB2R,ADRBR,B2AR,Badm,BAR,BETA2AR,Gpcr7
    Uniprot Accession P07550
    Uniprot Entry Name ADRB2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000169252
    Target Classification GPCR, Tumor-associated antigen (TAA)

    This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]



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