Human CHRNA7/CHRNA7-2/NACHRA7 ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (NM_000746)

Cat. No.: pGMPC000613
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human CHRNA7/CHRNA7-2/NACHRA7 Non-Viral expression plasmid (overexpression vector) for mouse CHRNA7 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC000613
Gene Name CHRNA7
Accession Number NM_000746
Gene ID 1139
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 1509 bp
Gene Alias CHRNA7-2,NACHRA7
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T34429-Ab Anti-ACHA7/ CHRNA7/ CHRNA7-2 monoclonal antibody
    Target Antigen GM-Tg-g-T34429-Ag CHRNA7 VLP (virus-like particle)
    ORF Viral Vector pGMLP001474 Human CHRNA7 Lentivirus plasmid
    ORF Viral Vector pGMPC000613 Human CHRNA7 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC004791 Human CHRNA7 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP001474 Human CHRNA7 Lentivirus particle


    Target information

    Target ID GM-T34429
    Target Name CHRNA7
    Gene ID 1139, 574230, 25302, 751113, 488696
    Gene Symbol and Synonyms BTX,CHRNA7,CHRNA7-2,NACHRA7,NARAD,nica7
    Uniprot Accession P36544
    Uniprot Entry Name ACHA7_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000175344
    Target Classification Ion Channel

    The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]



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