Human AGR2/AG-2/AG2 ORF/cDNA clone-Lentivirus plasmid (NM_006408.4)

Cat. No.: pGMLV001303
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human AGR2/AG-2/AG2 Lentiviral expression plasmid for AGR2 lentivirus packaging, AGR2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLV001303
Gene Name AGR2
Accession Number NM_006408.4
Gene ID 10551
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 528 bp
Gene Alias AG-2,AG2,GOB-4,HAG-2,HEL-S-116,HPC8,PDIA17,XAG-2
Fluorescent Reporter mCherry
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGAGAAAATTCCAGTGTCAGCATTCTTGCTCCTTGTGGCCCTCTCCTACACTCTGGCCAGAGATACCACAGTCAAACCTGGAGCCAAAAAGGACACAAAGGACTCTCGACCCAAACTGCCCCAGACCCTCTCCAGAGGTTGGGGTGACCAACTCATCTGGACTCAGACATATGAAGAAGCTCTATATAAATCCAAGACAAGCAACAAACCCTTGATGATTATTCATCACTTGGATGAGTGCCCACACAGTCAAGCTTTAAAGAAAGTGTTTGCTGAAAATAAAGAAATCCAGAAATTGGCAGAGCAGTTTGTCCTCCTCAATCTGGTTTATGAAACAACTGACAAACACCTTTCTCCTGATGGCCAGTATGTCCCCAGGATTATGTTTGTTGACCCATCTCTGACAGTTAGAGCCGATATCACTGGAAGATATTCAAATCGTCTCTATGCTTACGAACCTGCAGATACAGCTCTGTTGCTTGACAACATGAAGAAAGCTCTCAAGTTGCTGAAGACTGAATTGTAA
ORF Protein Sequence MEKIPVSAFLLLVALSYTLARDTTVKPGAKKDTKDSRPKLPQTLSRGWGDQLIWTQTYEEALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPADTALLLDNMKKALKLLKTEL

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T34352-Ab Anti-AGR2/ AG-2/ AG2 functional antibody
    Target Antigen GM-Tg-g-T34352-Ag AG-2/AGR2 protein
    ORF Viral Vector pGMLV001303 Human AGR2 Lentivirus plasmid
    ORF Viral Vector pGMAD001490 Human AGR2 Adenovirus plasmid
    ORF Viral Vector pGMAP000150 Human AGR2 Adenovirus plasmid
    ORF Viral Vector vGMLV001303 Human AGR2 Lentivirus particle
    ORF Viral Vector vGMAD001490 Human AGR2 Adenovirus particle
    ORF Viral Vector vGMAP000150 Human AGR2 Adenovirus particle


    Target information

    Target ID GM-T34352
    Target Name AG-2
    Gene ID 10551, 23795, 709127, 298961, 101084694, 482333, 415112, 100053075
    Gene Symbol and Synonyms AG-2,AG2,AGR2,Agr2h,GOB-4,HAG-2,HEL-S-116,HPC8,mAG-2,PDIA17,RIFTD,XAG-2
    Uniprot Accession O95994
    Uniprot Entry Name AGR2_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target
    Disease Prostate Cancer, Malignant neoplasm of prostate
    Gene Ensembl ENSG00000106541
    Target Classification Not Available

    This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]



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