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Human SNCA/NACP/PARK1 ORF/cDNA clone-Lentivirus plasmid (NM_000345.3)
SKU: pGMLV000451
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days
Pre-made Human SNCA/NACP/PARK1 Lentiviral expression plasmid for SNCA lentivirus packaging, SNCA lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.
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Product Description
| Catalog ID | pGMLV000451 |
| Gene Name | SNCA |
| Accession Number | NM_000345.3 |
| Gene ID | 6622 |
| Species | Human |
| Product Type | Lentivirus plasmid (overexpression) |
| Insert Length | 423 bp |
| Gene Alias | NACP,PARK1,PARK4,PD1 |
| Fluorescent Reporter | ZsGreen |
| Mammalian Cell Selection | Puromyocin |
| Fusion Tag | 3xflag (C-Terminal) |
| Promoter | CMV |
| Resistance | Amplicin |
Reference
Data / case study
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Associated products
Target information
| Target ID | GM-T03644 |
| Target Name | SNCA |
| Gene ID | 6622, 20617, 706985, 29219, 101091694, 478478, 282857, 100053270 |
| Gene Symbol and Synonyms | alpha-Syn,alphaSYN,NACP,PARK1,PARK4,PD1,SNCA |
| Uniprot Accession | P37840 |
| Uniprot Entry Name | SYUA_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Diagnostics Biomarker, INN Index |
| Disease | Not Available |
| Gene Ensembl | ENSG00000145335 |
| Target Classification | Not Available |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
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