Human TGFB1/CED/DPD1 ORF/cDNA clone-Lentivirus plasmid (NM_000660.6)

Cat. No.: pGMLP-SPh-037
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human TGFB1/CED/DPD1 Lentiviral expression plasmid for TGFB1 lentivirus packaging, TGFB1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP-SPh-037
Gene Name TGFB1
Accession Number NM_000660.6
Gene ID 7040
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 1173 bp
Gene Alias CED,DPD1,LAP,TGFB,TGFbeta
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Biosimilar GMP-Bios-ab-223 Pre-Made Fresolimumab biosimilar, Whole mAb, Anti-TGFB/TGFB1 Antibody: Anti-CED/DPD1/IBDIMDE/LAP therapeutic antibody
    Biosimilar GMP-Bios-INN-793 Pre-Made Dalutrafusp Alfa P Alfaiosimilar, Bispecific, Anti-NT5E/CD73;TGFB1;TGFB3 Antibody: Anti-eN/NTE/eNT/CALJA;CED/DPD1/IBDIMDE/LAP/TGF-beta1/TGFbeta;ARVD/ARVD1/LDS5/RNHF therapeutic antibody
    Biosimilar GMP-Bios-INN-908 Pre-Made Metelimumab Biosimilar, Whole Mab, Anti-Tgfb1 Antibody: Anti-CED/DPD1/IBDIMDE/LAP therapeutic antibody
    Target Antibody GM-Tg-g-T97257-Ab Anti-TGFB1/ CED/ DPD1 monoclonal antibody
    Target Antigen GM-Tg-g-T97257-Ag TGFB1 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-T97257 transforming growth factor, beta 1 (TGFB1) protein & antibody
    ORF Viral Vector pGMLP001905 Human TGFB1 Lentivirus plasmid
    ORF Viral Vector pGMAD000018 Human TGFB1 Adenovirus plasmid
    ORF Viral Vector pGMAD000417 Human TGFB1 Adenovirus plasmid
    ORF Viral Vector pGMAP000212 Human CED Adenovirus plasmid
    ORF Viral Vector pGMLP-SPh-037 Human TGFB1 Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-177 Human TGFB1 Adenovirus plasmid
    ORF Viral Vector pGMPC000678 Human TGFB1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001029 Human TGFB1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP001905 Human TGFB1 Lentivirus particle
    ORF Viral Vector vGMAD000018 Human TGFB1 Adenovirus particle
    ORF Viral Vector vGMAD000417 Human TGFB1 Adenovirus particle
    ORF Viral Vector vGMAP000212 Human CED Adenovirus particle
    ORF Viral Vector vGMLP-SPh-037 Human TGFB1 Lentivirus particle
    ORF Viral Vector vGMAP-SPh-177 Human TGFB1 Adenovirus particle


    Target information

    Target ID GM-T97257
    Target Name TGFB1
    Gene ID 7040, 21803, 106992315, 59086, 768263, 403998, 282089, 100033900
    Gene Symbol and Synonyms CED,DPD1,IBDIMDE,LAP,TGF-beta,TGF-beta1,TGFB,Tgfb-1,TGFB1,TGFbeta,TGFbeta1
    Uniprot Accession P01137
    Uniprot Entry Name TGFB1_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    Disease bladder cancer, Chronic Kidney Disease, Diabetic Nephropathy, Type 2 diabetes mellitus, Type 1 diabetes mellitus, Sickle Cell Nephropathy, Renal tubulo-interstitial diseases, Malignant neoplasm of bladder, Lupus Glomerulonephritis, Kidney disease
    Gene Ensembl ENSG00000105329
    Target Classification Checkpoint-Immuno Oncology

    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]



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