An ADC of an Anti-MTX mAb with Methotrexate (MTX) would, in principle, conjugate with cells containing the chemotherapeutic agent MTX based on the latter’s capacity to hinder dihydrofolate reductase. This enables the targeted delivery to increase MTX’s ability to suppress cell growth and division especially in cancer cells, a factor which will reduce its systemic toxicity. However, this specific approach belongs to a bit later and is not an official application of the currently used ADC technology.
Check the application of Methotrexate (MTX) in ADCs
Order information
| Catalog No. |
Product Name |
Size |
Price(In USD) |
| GTU-Bios-MTX-Ab-1 |
Anti-MTX (Methotrexate) human monoclonal antibody (mAb) |
1mg |
1690 |
| GTU-Bios-MTX-Ab-2 |
Anti-MTX (Methotrexate) mouse monoclonal antibody (mAb) |
1mg |
1690 |
| GTU-Bios-MTX-Ab-3 |
Anti-MTX (Methotrexate) mouse monoclonal antibody (mAb) |
1mg |
1690 |
Size： 1mg | 10mg | 100mg
Description
Anti-MTX (Methotrexate) human
monoclonal antibody (mAb)
| Cat No. |
GTU-Bios-MTX-Ab-1 |
| Product Name |
Anti-MTX (Methotrexate) human
monoclonal antibody (mAb) |
| Target |
Methotrexate (MTX) |
| Expression platform |
mammalian cell |
| Isotypes |
Human IgG1 |
| Bioactivity validation |
Methotrexate (MTX) binding,
Competitive immunoassay validation (Competitive ELISA) in Methotrexate (MTX) level test.
|
| Tag |
hFc |
| Products description |
Anti-Methotrexate (MTX) monoclonal
antibody is expressed from mammalian cell. |
| Species |
Human |
| Purity |
Purity: ≥95% (SDS-PAGE) |
| Application |
Competitive immunoassay validation
(Competitive ELISA) and other Immunoassay, PK & PD assay for MTX payload of
Antibody-drug Conjugate (ADC). |
| Formulation |
Lyophilized from sterile PBS, PH 7.4
|
| Storage |
Store at -20℃ to -80℃ under sterile
conditions. Avoid repeated freeze-thaw cycles. |
Anti-MTX (Methotrexate) mouse
monoclonal antibody (mAb)
| Cat No. |
GTU-Bios-MTX-Ab-2,
GTU-Bios-MTX-Ab-3 |
| Product Name |
Anti-MTX (Methotrexate) mouse
monoclonal antibody (mAb) |
| Target |
Methotrexate (MTX) |
| Expression platform |
mammalian cell |
| Isotypes |
Mouse IgG |
| Bioactivity validation |
Methotrexate (MTX) binding,
Competitive immunoassay validation (Competitive ELISA) in Methotrexate (MTX) level test.
|
| Tag |
mFc |
| Products description |
Anti-Methotrexate (MTX)) mouse
monoclonal antibody (mAb) is expressed from mammalian cell. |
| Species |
Mouse |
| Purity |
Purity: ≥95% (SDS-PAGE) |
| Application |
Competitive immunoassay validation
(Competitive ELISA) and other Immunoassay, PK & PD assay for MTX payload of
Antibody-drug Conjugate (ADC). |
| Formulation |
Lyophilized from sterile PBS, PH 7.4
|
| Storage |
Store at -20℃ to -80℃ under sterile
conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
Click to get more Data
/ Case study about the product.
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