Anti-MTX (Methotrexate) monoclonal antibody (mAb)

An ADC of an Anti-MTX mAb with Methotrexate (MTX) would, in principle, conjugate with cells containing the chemotherapeutic agent MTX based on the latter’s capacity to hinder dihydrofolate reductase. This enables the targeted delivery to increase MTX’s ability to suppress cell growth and division especially in cancer cells, a factor which will reduce its systemic toxicity. However, this specific approach belongs to a bit later and is not an official application of the currently used ADC technology.

Check the application of Methotrexate (MTX) in ADCs


pdfMSDSpdfCOApdfDatasheet

Order information


Catalog No. Product Name Size Price(In USD)
GTU-Bios-MTX-Ab-1 Anti-MTX (Methotrexate) human monoclonal antibody (mAb) 1mg 1690
GTU-Bios-MTX-Ab-2 Anti-MTX (Methotrexate) mouse monoclonal antibody (mAb) 1mg 1690
GTU-Bios-MTX-Ab-3 Anti-MTX (Methotrexate) mouse monoclonal antibody (mAb) 1mg 1690

Size： 1mg | 10mg | 100mg


Description


Anti-MTX (Methotrexate) human monoclonal antibody (mAb)

Cat No. GTU-Bios-MTX-Ab-1
Product Name Anti-MTX (Methotrexate) human monoclonal antibody (mAb)
Target Methotrexate (MTX)
Expression platform mammalian cell
Isotypes Human IgG1
Bioactivity validation Methotrexate (MTX) binding, Competitive immunoassay validation (Competitive ELISA) in Methotrexate (MTX) level test.
Tag hFc
Products description Anti-Methotrexate (MTX) monoclonal antibody is expressed from mammalian cell.
Species Human
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MTX payload of Antibody-drug Conjugate (ADC).
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-MTX (Methotrexate) mouse monoclonal antibody (mAb)

Cat No. GTU-Bios-MTX-Ab-2, GTU-Bios-MTX-Ab-3
Product Name Anti-MTX (Methotrexate) mouse monoclonal antibody (mAb)
Target Methotrexate (MTX)
Expression platform mammalian cell
Isotypes Mouse IgG
Bioactivity validation Methotrexate (MTX) binding, Competitive immunoassay validation (Competitive ELISA) in Methotrexate (MTX) level test.
Tag mFc
Products description Anti-Methotrexate (MTX)) mouse monoclonal antibody (mAb) is expressed from mammalian cell.
Species Mouse
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MTX payload of Antibody-drug Conjugate (ADC).
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    Click to get more Data / Case study about the product.



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