Anti-Exatecan (Exatecan Mesylate) monoclonal antibody (mAb)

Anti-Exatecan monoclonal antibody (mAb) for ADC is designed and developed for selective cancer therapy, targeting Exatecan Mesylate, a topoisomerase I inhibitor, to cancer cells. Exatecan binds and inhibits topoisomerase I, which is involved in DNA replication and causes cancer cells to die without affecting other cells.

Check the application of Exatecan Mesylate (Exatecan) in ADCs


pdfMSDSpdfCOApdfDatasheet

Order information


Catalog No. Product Name Size Price(In USD)
GTU-Bios-Exatecan-Ab-1 Anti-Exatecan (Exatecan Mesylate) human monoclonal antibody (mAb) 1mg 1690
GTU-Bios-Exatecan-Ab-2 Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) 1mg 1690
GTU-Bios-Exatecan-Ab-3 Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) 1mg 1690
GTU-Bios-Exatecan-Ab-1 Anti-Exatecan (Exatecan Mesylate) human monoclonal antibody (mAb) 100μg 310
GTU-Bios-Exatecan-Ab-2 Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) 100μg 310
GTU-Bios-Exatecan-Ab-3 Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb) 100μg 310
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Size： 1mg | 10mg | 100mg


Description


Anti-Exatecan (Exatecan Mesylate) human monoclonal antibody (mAb)

Cat No. GTU-Bios-Exatecan-Ab-1
Product Name Anti-Exatecan (Exatecan Mesylate) human monoclonal antibody (mAb)
Target Exatecan Mesylate (Exatecan)
Expression platform mammalian cell
Isotypes Human IgG1
Bioactivity validation Exatecan Mesylate (Exatecan) binding, Competitive immunoassay validation (Competitive ELISA) in Exatecan Mesylate (Exatecan) level test.
Tag hFc
Products description Anti-Exatecan Mesylate (Exatecan) monoclonal antibody is expressed from mammalian cell.
Species Human
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for Exatecan payload of Antibody-drug Conjugate (ADC).
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb)

Cat No. GTU-Bios-Exatecan-Ab-2, GTU-Bios-Exatecan-Ab-3
Product Name Anti-Exatecan (Exatecan Mesylate) mouse monoclonal antibody (mAb)
Target Exatecan Mesylate (Exatecan)
Expression platform mammalian cell
Isotypes Mouse IgG
Bioactivity validation Exatecan Mesylate (Exatecan) binding, Competitive immunoassay validation (Competitive ELISA) in Exatecan Mesylate (Exatecan) level test.
Tag mFc
Products description Anti-Exatecan Mesylate (Exatecan)) mouse monoclonal antibody (mAb) is expressed from mammalian cell.
Species Mouse
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for Exatecan payload of Antibody-drug Conjugate (ADC).
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    GeneMedi’s Anti-Exatecan Antibodies Exhibit High Specificity


    GeneMedi's GTU-Bios-Exatecan-Ab demonstrates specific binding affinity for Exatecan ADCs, highlighting its functional efficacy. Furthermore, its lack of binding to SN38-conjugated ADCs emphasizes GeneMedi's dedication to developing highly selective antibody solutions.

    Exatecan-Figure-Validation-1

    Figure 1. GeneMedi's GTU-Bios-Exatecan-Ab: Specific Binding with Exatecan, Not Binding with SN38.
    A. Exatecan ADC binding activity assay results show that the EC50 of GTU-Bios-Exatecan-Ab-2 is 0.06271 nM, while the EC50 of GTU-Bios-Exatecan-Ab-3 is 0.07254 nM, indicating strong binding affinity for Exatecan ADC.
    B. Both GTU-Bios-Exatecan-Ab-2 and GTU-Bios-Exatecan-Ab-3 are not available (N.A.) in the SN38 ADC binding assay.

    Click to get more Data / Case study about the product.



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