Anti-DXd/Exatecan monoclonal antibody (mAb)

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Utilizing our specific Anti-DXd/Exatecan Monoclonal Antibody can target and quantify, accurately, DXd/Exatecan related ADCs effectively as our product facilitates large-scale pharmacokinetic evaluations. Essential to the understanding of ADCs’ life cycle, such assessment offers a valuable insight of their absorption, distribution, and elimination phases to help optimize use of ADC-based therapies.

Check the Technical Information


Dxd structure

Order information


Catalog No. Product Name Size Price(In USD)
GTU-Bios-DXd-Ab-1 Anti-DXd/Exatecan human monoclonal antibody (mAb) 1mg 1690
GTU-Bios-DXd-Ab-2 Anti-DXd/Exatecan mouse monoclonal antibody (mAb) 1mg 1690
GTU-Bios-DXd-Ab-3 Anti-DXd/Exatecan mouse monoclonal antibody (mAb) 1mg 1690

Size: 1mg | 10mg | 100mg




Description


Anti-DXd/Exatecan human monoclonal antibody (mAb)

Cat No. GTU-Bios-DXd-Ab-1
Product Name Anti-DXd/Exatecan human monoclonal antibody (mAb)
Target Deruxtecan (DXd) / Exatecan
Expression platform mammalian cell
Isotypes Human IgG1
Bioactivity validation Deruxtecan (DXd) / Exatecan binding, Competitive immunoassay validation (Competitive ELISA) in Deruxtecan (DXd) / Exatecan level test.
Tag hFc
Products description Anti-Deruxtecan (DXd) / Exatecan monoclonal antibody is expressed from mammalian cell.
Species Human
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for DXd & Exatecan payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-DXd/Exatecan mouse monoclonal antibody (mAb)

Cat No. GTU-Bios-DXd-Ab-2, GTU-Bios-DXd-Ab-3
Product Name Anti-DXd/Exatecan mouse monoclonal antibody (mAb)
Target Deruxtecan (DXd) / Exatecan
Expression platform mammalian cell
Isotypes Mouse IgG
Bioactivity validation Deruxtecan (DXd) / Exatecan binding, Competitive immunoassay validation (Competitive ELISA) in Deruxtecan (DXd) / Exatecan level test.
Tag mFc
Products description Anti-Deruxtecan (DXd) / Exatecan) mouse monoclonal antibody (mAb) is expressed from mammalian cell.
Species Mouse
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for DXd & Exatecan payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    • Figure 1: Specific Binding with DXd
    • Figure 2: minimal impact on pharmacokinetic (PK) studies
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    Figure 1. GeneMedi's GTU-Bios-DXd-Ab: Specific Binding with DXd, Not Binding with SN38.

    GeneMedi's GTU-Bios-DXd-Ab exhibits specific binding to DXd-based ADCs, demonstrating its effectiveness. Moreover, it does not bind to ADCs conjugated with SN38, underscoring GeneMedi's commitment to producing highly selective antibodies.

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    Figure 2. GTU-Bios-DXd-Ab has minimal impact on pharmacokinetic (PK) studies involving humans and monkeys.

    GTU-Bios-DXd-Ab demonstrates minimal influence in PK studies with humans and monkeys, rendering it appropriate for application in these experiments.

    Click to get more Data / Case study about the product.



    Associated products


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    GTU-Bios-Auristatin-Ab-02 Anti-MMAE (Specific) monoclonal antibody(mAb) More Details
    GTU-Bios-DXd-Ab Anti-DXd&Exatecan monoclonal antibody(mAb) More Details
    GTU-Bios-CPT-Ab Anti-CPTmonoclonal antibody(mAb) More Details
    GTU-Bios-Eribulin-Ab Anti-Eribulin monoclonal antibody(mAb) More Details
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    Technical Resource


    The Knowledge base of Antibody-drug Conjugate (ADC)
  • The Landscape of ADC: Production, MOA, FDA approved-antibodies, and Functional assay
  • What is antibody-drug conjugate (ADC)?
  • Antibody-drug conjugate (ADC) in clinical application (Approved/BLA, phaseI/II/III)
  • Main elements of antibody-drug conjugate (ADC): Antibodies and their targets
  • Main elements of antibody-drug conjugate (ADC): Linker (structure and mechanism)
  • Main elements of antibody-drug conjugate (ADC): Toxins/Payloads (Classification and function)
  • Toxins/Payloads (Classification and function) of Microtubule destroying drug
  • Toxins/Payloads (Classification and function) of DNA damage drugs
  • Toxins/Payloads (Classification and function) of Innovative drugs
  • Biological coupling technology Chemical based specific in situ antibody modification
  • Endogenous coupling of amino acids and Disulfide re bridging strategy
  • Glycan coupling
  • Site specific biological coupling of engineered antibodies and Enzymatic method
  • Biological coupling with engineered unnatural amino acids
  • Review for ADC production, quality control and functional assay
  • Product data of ADC

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