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AAV-PHP.S vector system (AAV-PHP.S expression and packaging plasmid system, across the blood-brain barrier(BBB) ) (Amp and Kanamycin) (GeneMedi Owned)
GeneMedi (GM) AAV-PHP.S Vector system is including: 1) AAV-PHP.S Rep-Cap plasmid (AAV-PHP.S-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).
You can produce AAV-PHP.S particle in 293T cell line in high titer using GeneMedi's AAV-PHP.S Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.
With the blood-brain barrier(BBB) crossing propertiy, AAV-PHP.B shows potential applications in CNS (neuron) gene therapy, especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).
GeneMedi offers both Ampicillin (Amp) resistance and Kanamycin (Kan) resistance for the AAV Rep-Cap Plasmids, AAV expression Plasmids and AAV helper Plasmid.
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Product Description
| Cat.NO | Product Name | Organization Type | Price(In USD) | ||
|---|---|---|---|---|---|
| P-PK21 | AAV-PHP.S Vector System (Amp resistance) 1. AAV-PHP.S Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Academic | 2664 | ||
| P-PK21 | AAV-PHP.S Vector System (Amp resistance) 1. AAV-PHP.S Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Biotech & Pharma & Medical Device & Diagnostics | |||
| P-PK21 | AAV-PHP.S Vector System (Amp resistance) 1. AAV-PHP.S Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | CRO&CDMO& CXO&CMC& Manufacturing company |
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| P-PK21 | AAV-PHP.S Vector System (Amp resistance) 1. AAV-PHP.S Rep-Cap Plasmid, ≥10mg 2. AAV Helper Plasmid, ≥10mg 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01-Kan), ≥10mg |
All | |||
| P-PK21-Kan | AAV-PHP.S Vector System (Kan resistance) 1. AAV-PHP.S Rep-Cap Plasmid (Kan resistance) , ≥10mg 2. AAV Helper Plasmid (Kan resistance) , ≥10mg 3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), ≥10mg |
All | |||
| P-RC21 | AAV-PHP.S Rep-Cap
Plasmid (Amp resistance)
Size：5ug |
Academic | 1308 | ||
| P-RC21 | AAV-PHP.S Rep-Cap
Plasmid (Amp resistance)
Size：5ug | Biotech & Pharma & Medical Device & Diagnostics | |||
| P-RC21 | AAV-PHP.S Rep-Cap
Plasmid (Amp resistance)
Size：5ug | CRO&CDMO& CXO&CMC& Manufacturing company |
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| P-RC21 | AAV-PHP.S Rep-Cap
Plasmid (Amp resistance)
Size：≥10mg |
All | |||
| P-RC21-Kan | AAV-PHP.S Rep-Cap
Plasmid(Kan resistance)
Size：≥10mg |
All | |||
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GeneMedi offers both seed and amplification services for the Amp-resistant AAV Vector System. GeneMedi only offers amplification services and do not provide seed for the Kan-resistant AAV Vector System currently. |
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| If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service. | |||||
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Terms of sale: For Seed (5ug): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party. For plasmid production& amplification (≥10mg): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party. |
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Citation
| Title | Publication | Date |
|---|---|---|
| The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation | Signal Transduction and Targeted Therapy | 2023/9/21 |
| Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration | Molecular Cancer | 2018/10/6 |
| Cobaltosic oxide-polyethylene glycol-triphenylphosphine nanoparticles ameliorate the acute-to-chronic kidney disease transition by inducing BNIP3-mediated mitophagy | Kidney international | |
| TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage | Nature communications | 2022/12/2 |
| AKAP1 Deficiency Attenuates Diet-Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes | Advanced Science | 2021/2/1 |
| The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression | Cancer Communications | 2022/7/18 |
| Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer | Acta Pharmaceutica Sinica B | 2022/10/28 |
| Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells | Journal for ImmunoTherapy of Cancer | 2021/12/1 |
| Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression | Journal of Sport and Health Science | 2022/10/29 |
| Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles | Theranostics | 2024/1/1 |
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Associated products and services
| Products & Service | Products & Service Information |
|---|---|
| AAV Packaging service | Detail |
| Promise-ORF™ viral CDNA library | Detail |
| Plasmid DNA Rapid Preparation Service | Detail |
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