cardiac troponin T (cTnT) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-cTnT-Ag01	Recombinant human TNNT2/cTnT Protein	3090
GMP-h-cTnT-Ab01	Anti-human TNNT2/cTnT mouse monoclonal antibody (mAb)	1953
GMP-h-cTnT-Ab02	Anti-human TNNT2/cTnT mouse monoclonal antibody (mAb)	1953
GMP-h-cTnT-Ab03	Anti-human TNNT2/cTnT human monoclonal antibody (mAb)	1953
GMP-h-cTnT-Ab04	Anti-human TNNT2/cTnT human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-h-cTnT-Ag01
Product Name	Recombinant human TNNT2/cTnT Protein
Target/Biomarker	cardiac troponin T (cTnT)
Alias of Target/Biomarker	CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	cardiac troponin T (cTnT) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnT level test of Cardiovascular disease (hypertrophic cardiomyopathy, restrictive and dilated cardiomyopathy. ) and related syndrome evaluation.
Tag	His
Products description	Recombinant human TNNT2/cTnT Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-cTnT-Ab01, GMP-h-cTnT-Ab02
Product Name	Anti-human TNNT2/cTnT mouse monoclonal antibody (mAb)
Target/Biomarker	cardiac troponin T (cTnT)
Alias of Target/Biomarker	CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	cardiac troponin T (cTnT) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnT level test of Cardiovascular disease (hypertrophic cardiomyopathy, restrictive and dilated cardiomyopathy. ) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human TNNT2/cTnT mouse monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-cTnT-Ab03, GMP-h-cTnT-Ab04
Product Name	Anti-human TNNT2/cTnT human monoclonal antibody (mAb)
Target/Biomarker	cardiac troponin T (cTnT)
Alias of Target/Biomarker	CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	cardiac troponin T (cTnT) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnT level test of Cardiovascular disease (hypertrophic cardiomyopathy, restrictive and dilated cardiomyopathy. ) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human TNNT2/cTnT human monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

cTnT) is a protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.As part of the Troponin complex, the function of cTnT is to regulate muscle contraction. The N-terminal region of TnT that strongly binds actin most likely moves with Tm and actin during strong myosin crossbridge binding and force generation. This region is likely involved in the transduction of cooperativity down the thin filament.[14] The C-terminal region of TnT constitutes part of the globular troponin complex domain, and participates in employing the calcium sensitivity of strong myosin crossbridge binding to the thin filament.[15]Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with restrictive[16] and dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.[17] Mutations of this gene may be associated with mild or absent hypertrophy and predominant restrictive disease, with a high risk of sudden cardiac death.[16] Advancement to dilated cardiomyopathy may be more rapid in patients with TNNT2 mutations than in those with myosin heavy chain mutations.

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