Cardiac troponin I (cTnI) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-cTnI-Ag01	Recombinant human TNNI3/cTnI/TNNC1 Protein	3090
GMP-h-cTnI-Ab01	Anti-human TNNI3/cTnI/TNNC1 mouse monoclonal antibody (mAb)	1953
GMP-h-cTnI-Ab02	Anti-human TNNI3/cTnI/TNNC1 mouse monoclonal antibody (mAb)	1953
GMP-h-cTnI-Ab03	Anti-human TNNI3/cTnI/TNNC1 human monoclonal antibody (mAb)	1953
GMP-h-cTnI-Ab04	Anti-human TNNI3/cTnI/TNNC1 human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-h-cTnI-Ag01
Product Name	Recombinant human TNNI3/cTnI/TNNC1 Protein
Target/Biomarker	Cardiac troponin I (cTnI)
Alias of Target/Biomarker	CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Cardiac troponin I (cTnI) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnI level test of Cardiovascular disease ( myocardial infarction ) and related syndrome evaluation.
Tag	His
Products description	Recombinant human TNNI3/cTnI/TNNC1 Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-cTnI-Ab01, GMP-h-cTnI-Ab02
Product Name	Anti-human TNNI3/cTnI/TNNC1 mouse monoclonal antibody (mAb)
Target/Biomarker	Cardiac troponin I (cTnI)
Alias of Target/Biomarker	CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Cardiac troponin I (cTnI) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnI level test of Cardiovascular disease ( myocardial infarction ) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human TNNI3/cTnI/TNNC1 mouse monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-cTnI-Ab03, GMP-h-cTnI-Ab04
Product Name	Anti-human TNNI3/cTnI/TNNC1 human monoclonal antibody (mAb)
Target/Biomarker	Cardiac troponin I (cTnI)
Alias of Target/Biomarker	CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Cardiac troponin I (cTnI) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnI level test of Cardiovascular disease ( myocardial infarction ) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human TNNI3/cTnI/TNNC1 human monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Cardiac troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with a molecular weight of 23.9 kDa. It consists of 209 amino acid residues. The theoretical pI of cTnI is 9.05.[3] cTnI differs from other troponins due to its N-terminal extension of 26 amino acids. This extension contains two serines, residues 23 and 24, which are phosphorylated by protein kinase A in response to beta-adrenergic stimulation and important in increasing the inotropic response.[4] Phosphorylation of cTnI changes the conformation of the protein and modifies its interaction with other troponins as well as the interaction with anti-TnI antibodies. These changes alter the myofilament response to calcium, and are of interest in targeting heart failure. Multiple reaction monitoring of cTnI has revealed that there are 14 phosphorylation sites and the pattern of phosphorylation observed these sites is changed in response to disease.[5] cTnI has been shown to be phosphorylated by protein kinase A, protein kinase C, protein kinase G, and p21-activated kinase 3.[6] A significant part of cTnI released into the patient's blood stream is phosphorylated.[7] For more than 15 years cTnI has been known as a reliable marker of cardiac muscle tissue injury. It is considered to be more sensitive and significantly more specific in diagnosis of the myocardial infarction than the "golden marker" of last decades – CK-MB, as well as total creatine kinase, myoglobin and lactate dehydrogenase isoenzymes.

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