Proinsulin antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-Proinsulin-Ag01	Recombinant human INS/Proinsulin Protein	3090
GMP-h-Proinsulin-Ab01	Anti-human INS/Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-h-Proinsulin-Ab02	Anti-human INS/Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-h-Proinsulin-Ab03	Anti-human INS/Proinsulin human monoclonal antibody (mAb)	1953
GMP-h-Proinsulin-Ab04	Anti-human INS/Proinsulin human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-h-Proinsulin-Ag01
Product Name	Recombinant human INS/Proinsulin Protein
Target/Biomarker	Proinsulin (Proinsulin)
Alias of Target/Biomarker	IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Proinsulin (Proinsulin) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Proinsulin level test of Diabetes diseases (type 2 diabetes) and related syndrome evaluation.
Tag	His
Products description	Recombinant human INS/Proinsulin Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-Proinsulin-Ab01, GMP-h-Proinsulin-Ab02
Product Name	Anti-human INS/Proinsulin mouse monoclonal antibody (mAb)
Target/Biomarker	Proinsulin (Proinsulin)
Alias of Target/Biomarker	IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Proinsulin (Proinsulin) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Proinsulin level test of Diabetes diseases (type 2 diabetes) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human INS/Proinsulin mouse monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-Proinsulin-Ab03, GMP-h-Proinsulin-Ab04
Product Name	Anti-human INS/Proinsulin human monoclonal antibody (mAb)
Target/Biomarker	Proinsulin (Proinsulin)
Alias of Target/Biomarker	IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Proinsulin (Proinsulin) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Proinsulin level test of Diabetes diseases (type 2 diabetes) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human INS/Proinsulin human monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. Increased levels of proinsulin in the circulatory system relative to mature insulin concentrations can indicate impending insulin resistance and the development of type 2 diabetes. Postnatal proinsulin is crucial for metabolic regulation. However, proinsulin in neonates is important for normal development of the nerves of the eye, development of the heart, and general survival of embryonic cells. Regulation of the concentration of proinsulin during embryonic development is crucial, as too much or too little of the peptide can cause defects and death of the fetus.

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