N-terminal midfragment of Osteocalcin (N-MID OC) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-N-MID-OC-Ag01	Recombinant human BGLAP/N-MID OC Protein	3090
GMP-h-N-MID-OC-Ab01	Anti-human BGLAP/N-MID OC mouse monoclonal antibody (mAb)	1953
GMP-h-N-MID-OC-Ab02	Anti-human BGLAP/N-MID OC mouse monoclonal antibody (mAb)	1953
GMP-h-N-MID-OC-Ab03	Anti-human BGLAP/N-MID OC human monoclonal antibody (mAb)	1953
GMP-h-N-MID-OC-Ab04	Anti-human BGLAP/N-MID OC human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-h-N-MID-OC-Ag01
Product Name	Recombinant human BGLAP/N-MID OC Protein
Target/Biomarker	N-terminal midfragment of Osteocalcin (N-MID OC)
Alias of Target/Biomarker	BGP, OC, OCN
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	N-terminal midfragment of Osteocalcin (N-MID OC) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in N-MID OC level test of Metabolic diseases (osteoporosis) and related syndrome evaluation.
Tag	His
Products description	Recombinant human BGLAP/N-MID OC Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-N-MID-OC-Ab01, GMP-h-N-MID-OC-Ab02
Product Name	Anti-human BGLAP/N-MID OC mouse monoclonal antibody (mAb)
Target/Biomarker	N-terminal midfragment of Osteocalcin (N-MID OC)
Alias of Target/Biomarker	BGP, OC, OCN
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	N-terminal midfragment of Osteocalcin (N-MID OC) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in N-MID OC level test of Metabolic diseases (osteoporosis) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human BGLAP/N-MID OC mouse monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-N-MID-OC-Ab03, GMP-h-N-MID-OC-Ab04
Product Name	Anti-human BGLAP/N-MID OC human monoclonal antibody (mAb)
Target/Biomarker	N-terminal midfragment of Osteocalcin (N-MID OC)
Alias of Target/Biomarker	BGP, OC, OCN
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	N-terminal midfragment of Osteocalcin (N-MID OC) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in N-MID OC level test of Metabolic diseases (osteoporosis) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human BGLAP/N-MID OC human monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

The procollagen type I N-terminal propeptide (P1NP) and osteocalcin (OC) are the the most sensitive markers of bone formation rate. Although labile, assay of intact osteocalcin (iOC) is established as the standard assay for evaluating osteoblastic function. Study examines the clinical usefulness of the newly developed immunoradiometric assay for osteocalcin (OC), which identifies the stable N-terminal midfragment of OC (N-MID OC assay). The findings suggest that N-MID OC immunoreactivity is much more stable than iOC immunoreactivity and that N-MID OC assay may be less susceptible to the OC fragments reported to accumulate in uremic serum. It may, therefore, prove more reliable than iOC assay for evaluating bone turnover, and thus for reflecting bone loss.

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