myelin oligodendrocyte glycoprotein (MOG) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-MOG-Ag01	Recombinant human MOG Protein	3090
GMP-h-MOG-Ab01	Anti-human MOG mouse monoclonal antibody (mAb)	1953
GMP-h-MOG-Ab02	Anti-human MOG mouse monoclonal antibody (mAb)	1953
GMP-h-MOG-Ab03	Anti-human MOG human monoclonal antibody (mAb)	1953
GMP-h-MOG-Ab04	Anti-human MOG human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-h-MOG-Ag01
Product Name	Recombinant human MOG Protein
Target/Biomarker	myelin oligodendrocyte glycoprotein (MOG)
Alias of Target/Biomarker	BTN6, BTNL11, MOGIG2, NRCLP7
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	myelin oligodendrocyte glycoprotein (MOG) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in MOG level test of Inflammation/autoimmune/inflammatory disease (MOG antibody disease) and related syndrome evaluation.
Tag	His
Products description	Recombinant human MOG Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-MOG-Ab01, GMP-h-MOG-Ab02
Product Name	Anti-human MOG mouse monoclonal antibody (mAb)
Target/Biomarker	myelin oligodendrocyte glycoprotein (MOG)
Alias of Target/Biomarker	BTN6, BTNL11, MOGIG2, NRCLP7
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	myelin oligodendrocyte glycoprotein (MOG) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in MOG level test of Inflammation/autoimmune/inflammatory disease (MOG antibody disease) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human MOG mouse monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-MOG-Ab03, GMP-h-MOG-Ab04
Product Name	Anti-human MOG human monoclonal antibody (mAb)
Target/Biomarker	myelin oligodendrocyte glycoprotein (MOG)
Alias of Target/Biomarker	BTN6, BTNL11, MOGIG2, NRCLP7
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	myelin oligodendrocyte glycoprotein (MOG) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in MOG level test of Inflammation/autoimmune/inflammatory disease (MOG antibody disease) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human MOG human monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Myelin oligodendrocyte glycoprotein antibody disorders (MOGAD) is an idiopathic, inflammatory, demyelinating disease of the central nervous system (CNS). MOG is a glycoprotein uniquely expressed in oligodendrocytes in the CNS. MOG antibodies were originally thought to be involved in multiple sclerosis (MS), but subsequent studies found it to be a distinct disease. MOGAD have many similarities to neuromyelitis optica but several studies have demonstrated they have unique clinical features, treatment response, and prognosis. MOGAD were initially identified in NMOSD antibody negative patients. Pathologically NMOSD is classified as am astrocytopathy, while MOGAD are classified as oligodendrogliopathies. The MOG antibody can distinguish a spectrum of autoimmune demyelinating diseases from multiple sclerosis (MS). Testing positive for the MOG antibody indicates that a patient doesn't have classical MS. That's important because diseases associated with the MOG antibody — as well as diseases associated with the water channel aquaporin-4 (AQP4) antibody, which was discovered at Mayo Clinic — are commonly misdiagnosed as MS. Yet some MS medications have been reported to worsen diseases that mimic MS. Which patients would benefit from this antibody testing? Any patient who suddenly presents with vision loss, significant disk edema or recurrent optic neuritis should consider testing for both MOG and AQP4 antibodies. Patients who have more than one episode of optic neuritis absolutely should have testing. An optic neuritis seems to be a very common presentation of MOG.

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