Alpha-1-microglobulin (A1M) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-A1M-Ag01	Recombinant human AMBP/A1M/HCP/ITIL Protein	3090
GMP-h-A1M-Ab01	Anti-human AMBP/A1M/HCP/ITIL mouse monoclonal antibody (mAb)	1953
GMP-h-A1M-Ab02	Anti-human AMBP/A1M/HCP/ITIL mouse monoclonal antibody (mAb)	1953
GMP-h-A1M-Ab03	Anti-human AMBP/A1M/HCP/ITIL human monoclonal antibody (mAb)	1953
GMP-h-A1M-Ab04	Anti-human AMBP/A1M/HCP/ITIL human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-h-A1M-Ag01
Product Name	Recombinant human AMBP/A1M/HCP/ITIL Protein
Target/Biomarker	Alpha-1-microglobulin (A1M)
Alias of Target/Biomarker	A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Alpha-1-microglobulin (A1M) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in A1M level test of Kidney function (renal damages) (Proteinuria, preeclampsia,) and related syndrome evaluation.
Tag	His
Products description	Recombinant human AMBP/A1M/HCP/ITIL Protein was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-A1M-Ab01, GMP-h-A1M-Ab02
Product Name	Anti-human AMBP/A1M/HCP/ITIL mouse monoclonal antibody (mAb)
Target/Biomarker	Alpha-1-microglobulin (A1M)
Alias of Target/Biomarker	A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Alpha-1-microglobulin (A1M) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in A1M level test of Kidney function (renal damages) (Proteinuria, preeclampsia,) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human AMBP/A1M/HCP/ITIL mouse monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-A1M-Ab03, GMP-h-A1M-Ab04
Product Name	Anti-human AMBP/A1M/HCP/ITIL human monoclonal antibody (mAb)
Target/Biomarker	Alpha-1-microglobulin (A1M)
Alias of Target/Biomarker	A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Alpha-1-microglobulin (A1M) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in A1M level test of Kidney function (renal damages) (Proteinuria, preeclampsia,) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human AMBP/A1M/HCP/ITIL human monoclonal antibody (mAb) was expressed in CHO expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Urinary microproteins are becoming increasingly important in clinical diagnostics. They can contribute in the non-invasive early detection of renal abnormalities and the differentiation of various nephrological and urological pathologies. Alpha-1-microglobulin (A1M, α1-microglobulin, sometimes also called Protein HC) is a microglobulin, a small globular protein. It is found in all vertebrates, including humans, and is distributed in blood plasma and extravascular tissues of all organs. It is synthesized in most cells of the body, but mainly in the liver from a gene that codes for the alpha-1-microglobulin/bikunin precursor. A1M can be used as an indicator of proteinuria. The test can be regarded as positive when the ratio of A1M (in milligrams) and creatinine in millimoles in the urine is over 0.7 mg/mmol. A test for preeclampsia, where A1M serves as the diagnostic marker, has been proposed. It is based upon the fact that oxidative stress in the placenta tissue triggers the endogenous synthesis and plasma concentration of the protein.Alpha 1-microglobulin (A1M) is an immunomodulatory protein with a broad spectrum of possible clinical applications and seems a promising marker for evaluation of tubular function.

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