Candida krusei antibody and antigen (recombinant protein)

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Diagnostic anti-Candida krusei antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease Candidiasis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P270-Ag01	Recombinant Candida krusei protein	$3090.00
GMP-VT-P270-Ab01	Anti-Candida krusei mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P270-Ab02	Anti-Candida krusei mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P270-Ag01
Product Name	Recombinant Candida krusei protein
Pathogen	Candida krusei
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Candida krusei antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Candida krusei level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with Candidiasis.
Tag	His
Product description	Recombinant Candida krusei proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P270-Ab01,GMP-VT-P270-Ab02
Pathogen	Candida krusei
Product Name	Anti-Candida krusei mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Candida krusei antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Candida krusei antibodies in Candida krusei level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with Candidiasis.
Product description	Anti-Candida krusei mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Candida krusei antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Salmonella enterica subsp. enterica, often referred to simply as Salmonella enterica, is a pathogenic bacterium that falls within the family of Enterobacteriaceae. It is a gram-negative, rod-shaped bacterium that is facultative anaerobic, meaning it can survive in both the presence and absence of oxygen. This bacterium is a well-known and significant cause of infectious diseases in both humans and animals, which makes it a focus of extensive research and public health concern.

Genus and Species Classification:

Salmonella enterica is classified within the Salmonella genus, which is known for its pathogenic members. This genus is part of the broader Enterobacteriaceae family, which includes other clinically relevant bacteria like Escherichia coli. The species Salmonella enterica is further divided into numerous subspecies, with the "enterica" subspecies being one of the most clinically relevant and widely studied.

Structural Features:

Salmonella enterica's structural features play a crucial role in its pathogenicity. The bacterium possesses a cell envelope that includes an outer membrane, a peptidoglycan layer, and an inner membrane. One of the most notable structural components is the presence of flagella, which allow Salmonella to be highly motile. This motility is a key factor in its ability to infect host organisms, as it facilitates movement through various environments, including the human digestive system.

Pathogenicity and Virulence Factors:

Salmonella enterica is equipped with an array of virulence factors that enable it to cause disease. One of the most important genomic regions related to its pathogenicity is the Salmonella Pathogenicity Island (SPI). SPI contains a cluster of genes responsible for virulence factors, including the type III secretion system (T3SS) and its associated effector proteins. This system enables Salmonella to inject effector proteins directly into host cells, allowing it to manipulate cellular processes and avoid immune detection.

Host Range and Associated Diseases:

The host range of Salmonella enterica is broad and includes humans, livestock, and various wildlife species. In humans, Salmonella infection leads to a condition known as salmonellosis. This disease is characterized by symptoms such as diarrhea, abdominal cramps, nausea, vomiting, and fever. It can vary in severity, from a mild, self-limiting illness to severe cases requiring medical intervention.

In animals, Salmonella infection can result in diseases such as enteric fever, gastroenteritis, and septicemia. Contaminated food products, particularly those of animal origin, are common sources of human infection, highlighting the close relationship between human and animal health in Salmonella transmission.

Diagnostic Methods:

Accurate and timely diagnosis of Salmonella enterica infections is crucial for effective treatment and public health management. Several diagnostic methods are employed for this purpose:

1.Culture-Based Methods: These involve the isolation of the bacterium on selective agar media, such as MacConkey or Xylose Lysine Desoxycholate (XLD) agar. The characteristic colonies and biochemical tests are used for identification.

2.Polymerase Chain Reaction (PCR): PCR assays target specific genes within Salmonella enterica, such as the invA gene or the 16S rRNA gene. These tests can confirm the presence of the bacterium rapidly and accurately.

3.Serological Tests: Enzyme-linked immunosorbent assay (ELISA) and agglutination tests are used to detect Salmonella-specific antibodies or antigens in patient samples. These tests are especially useful for diagnosing chronic or persistent infections.

4.Whole Genome Sequencing (WGS): WGS has emerged as a powerful tool in the identification and characterization of Salmonella strains. It provides comprehensive genomic information, allowing for precise strain typing and tracking of outbreaks.

5.Nucleic Acid Hybridization: Techniques like DNA-DNA hybridization can be employed to identify Salmonella based on nucleic acid sequences. These methods are less common but can be useful in certain contexts.

In conclusion, Salmonella enterica subsp. enterica is a highly adaptable and pathogenic bacterium with a broad host range. Its ability to cause diseases in both humans and animals underscores its public health significance. Research on its genomic and structural features, along with the development of accurate diagnostic methods, is essential for the prevention and control of Salmonella infections. Understanding the intricacies of its pathogenicity and virulence factors also contributes to the development of effective therapeutic interventions and public health strategies to combat this infectious agent.

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