Aphthovirus/Foot and Mouth Disease Virus(FMDV) antibody and antigen (recombinant protein)

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Diagnostic anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) antibodies pairs and antigen for animal health (animal Bovines/Cattle, Ovines/Sheep, Swine/Porcine/Pig infectious disease Foot and Mouth Disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P257-Ag01	Recombinant Aphthovirus/Foot and Mouth Disease Virus(FMDV) protein	$3090.00
GMP-VT-P257-Ab01	Anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P257-Ab02	Anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P257-Ag01
Product Name	Recombinant Aphthovirus/Foot and Mouth Disease Virus(FMDV) protein
Pathogen	Aphthovirus/Foot and Mouth Disease Virus(FMDV)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aphthovirus/Foot and Mouth Disease Virus(FMDV) level test of animal Bovines/Cattle, Ovines/Sheep, Swine/Porcine/Pig infectious disease with Foot and Mouth Disease.
Tag	His
Product description	Recombinant Aphthovirus/Foot and Mouth Disease Virus(FMDV) proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P257-Ab01,GMP-VT-P257-Ab02
Pathogen	Aphthovirus/Foot and Mouth Disease Virus(FMDV)
Product Name	Anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Aphthovirus/Foot and Mouth Disease Virus(FMDV) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) antibodies in Aphthovirus/Foot and Mouth Disease Virus(FMDV) level test of animal Bovines/Cattle, Ovines/Sheep, Swine/Porcine/Pig infectious disease with Foot and Mouth Disease.
Product description	Anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Aphthovirus/Foot and Mouth Disease Virus(FMDV) antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Pathogen

Aphthovirus, also known as Foot-and-Mouth Disease Virus (FMDV), is a highly contagious pathogen that primarily infects cloven-hoofed animals. FMDV is classified as a member of the Picornaviridae family and is further categorized as a positive-sense RNA virus. The virus has a single-stranded RNA genome that encodes for a single polyprotein, which is subsequently cleaved into structural and non-structural proteins.

The structural proteins, VP1, VP2, VP3, and VP4, are responsible for viral replication and host-cell recognition. VP1 is the most variable of the structural proteins and plays a crucial role in determining the tropism of the virus for different host species. VP2 and VP3 are involved in the formation of the viral capsid, while VP4 is located on the inside of the capsid.

FMDV is a well-known animal pathogen that causes foot-and-mouth disease (FMD) in livestock. The disease is highly infectious and can spread rapidly through infected animals, contaminated surfaces, and even through the air. In addition to cattle, pigs, sheep, and goats, other members of the Artiodactyla order like deer and antelope can also become infected with FMDV.

The clinical signs of FMD infections are severe and include fever, vesicular lesions on the feet and mouth, and lameness. The lesions can also appear on the tongue, gums, and teats of female animals. FMD is not typically fatal, but it can cause significant economic losses due to reduced productivity, restrictions on animal movements, and trade barriers.

The diagnosis of FMD relies on laboratory tests such as enzyme-linked immunosorbent assay (ELISA), virus isolation, and reverse transcription-polymerase chain reaction (RT-PCR). ELISA and RT-PCR assays primarily target viral genome sequences or specific proteins such as VP1 or 3Dpol. Similarly, serology tests like the liquid-phase blocking ELISA can be used to detect antibodies against FMDV.

Preventing the spread of FMD is crucial and can be achieved through vaccination, biosecurity measures, and movement restrictions. Vaccination is an effective way of preventing FMD, but it can also interfere with the diagnosis of the disease. Biosecurity measures such as quarantine, disinfection, and animal movement controls can also limit the spread of the virus.

In conclusion, Aphthovirus or Foot-and-Mouth Disease Virus (FMDV) is a highly contagious pathogen that primarily infects cloven-hoofed animals. The virus causes foot-and-mouth disease (FMD), which leads to severe clinical signs such as fever, vesicular lesions on the feet and mouth, and lameness. Diagnosis of FMD relies on laboratory tests such as ELISA, virus isolation, and RT-PCR. Preventing the spread of FMD can be achieved through vaccination, biosecurity measures, and movement restrictions.

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