Pigeon circovirus antibody and antigen (recombinant protein)

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Diagnostic anti-Pigeon circovirus antibodies pairs and antigen for animal health (animal Pigeon infectious disease young pigeon disease syndrome) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P225-Ag01	Recombinant Pigeon circovirus protein	$3090.00
GMP-VT-P225-Ab01	Anti-Pigeon circovirus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P225-Ab02	Anti-Pigeon circovirus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P225-Ag01
Product Name	Recombinant Pigeon circovirus protein
Pathogen	Pigeon circovirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Pigeon circovirus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Pigeon circovirus level test of animal Pigeon infectious disease with young pigeon disease syndrome.
Tag	His
Product description	Recombinant Pigeon circovirus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P225-Ab01,GMP-VT-P225-Ab02
Pathogen	Pigeon circovirus
Product Name	Anti-Pigeon circovirus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Pigeon circovirus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pigeon circovirus antibodies in Pigeon circovirus level test of animal Pigeon infectious disease with young pigeon disease syndrome.
Product description	Anti-Pigeon circovirus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pigeon circovirus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Pathogen

PiCV is a small virus approximately 20 nm in diameter. The virus morphology is typical of circoviruses, with an icosahedral capsid composed of 60 copies of the capsid protein (Cap). The Cap protein is encoded by the Cap gene, which is located on the viral genome opposite the replication-associated protein (Rep) gene. The Cap protein is involved in virus attachment to host cells and is a major target of the host immune response.

The Rep gene encodes a multifunctional protein that is essential for viral DNA replication and is therefore critical for virus propagation. The Rep protein has several conserved motifs common to circoviruses, including those involved in DNA binding, helicase activity, and nuclease activity. Because of its crucial role in the virus life cycle, the Rep protein is a prime target for antiviral drugs.

PiCV primarily infects the respiratory and digestive tracts of pigeons and doves, although other organs such as the liver and spleen can also be affected. Clinical symptoms of PiCV infection are variable and can include weight loss, respiratory distress, diarrhea, immune suppression, and sudden death syndrome. PiCV infections are often complicated by secondary bacterial or fungal infections that can exacerbate these symptoms.

PiCV is transmitted between birds through direct contact with infected secretions or excretions, as well as through contaminated surfaces or fomites. The virus can also be transmitted vertically from infected mothers to their offspring, although the efficiency of this transmission route is not well understood.

Diagnosis of PiCV infection can be challenging because clinical symptoms are nonspecific and can resemble those of other avian respiratory or gastrointestinal diseases. Several diagnostic methods have been developed for PiCV, including nucleic acid-based techniques such as polymerase chain reaction (PCR) and DNA sequencing to detect viral DNA in infected birds. These methods typically target the Rep and Cap genes of the virus. Additionally, enzyme-linked immunosorbent assay (ELISA) has been used to detect viral antibodies in the serum of infected birds. Accurate diagnosis of PiCV infection is critical for effective disease control measures in pigeon flocks.

Prevention and control of PiCV infection can be achieved through good biosecurity practices, such as maintaining clean housing conditions and avoiding contact with birds from unknown sources. There are currently no licensed vaccines or antiviral drugs available for PiCV, although several research groups are working on developing these interventions.

In summary, Pigeon circovirus is a small, non-enveloped DNA virus that primarily infects pigeons and doves. Clinical symptoms of PiCV infection are variable and can include weight loss, respiratory distress, diarrhea, immune suppression, and sudden death syndrome. Diagnosis of PiCV infection can be challenging, but several diagnostic methods have been developed. Prevention and control of PiCV infection relies on good biosecurity practices. Further research efforts are needed to develop effective interventions against PiCV and other circoviruses that affect animal and human health.

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