Egg drop syndrome virus antibody and antigen (recombinant protein)

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Diagnostic anti-Egg drop syndrome virus antibodies pairs and antigen for animal health (animal Chicken, Goose, Duck, Quail infectious disease Egg drop syndrome '76) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P206-Ag01	Recombinant Egg drop syndrome virus protein	$3090.00
GMP-VT-P206-Ab01	Anti-Egg drop syndrome virus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P206-Ab02	Anti-Egg drop syndrome virus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P206-Ag01
Product Name	Recombinant Egg drop syndrome virus protein
Pathogen	Egg drop syndrome virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Egg drop syndrome virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Egg drop syndrome virus level test of animal Chicken, Goose, Duck, Quail infectious disease with Egg drop syndrome '76.
Tag	His
Product description	Recombinant Egg drop syndrome virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P206-Ab01,GMP-VT-P206-Ab02
Pathogen	Egg drop syndrome virus
Product Name	Anti-Egg drop syndrome virus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Egg drop syndrome virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Egg drop syndrome virus antibodies in Egg drop syndrome virus level test of animal Chicken, Goose, Duck, Quail infectious disease with Egg drop syndrome '76.
Product description	Anti-Egg drop syndrome virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Egg drop syndrome virus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Egg Drop Syndrome Virus (EDSV): Unraveling the Avian Adenoviral Culprit

Introduction:

Egg Drop Syndrome Virus (EDSV), also scientifically known as avian adenovirus, is a notorious pathogen that primarily targets avian species, most notably chickens. It is classified within the Aviadenovirus genus, a member of the Adenoviridae family. This virus has earned notoriety in the poultry industry for its ability to induce a significant and sudden decline in egg production, resulting in substantial economic losses for poultry farmers. In this detailed exploration, we will delve into the characteristics, structure, host range, associated diseases, and diagnostic methods employed in the context of EDSV.

Characteristics of EDSV:

At its core, EDSV is a non-enveloped virus with a distinctive icosahedral capsid structure. This structure encapsulates its DNA genome, which is a defining characteristic of adenoviruses. The capsid itself is primarily composed of proteins, and one of the key structural components is the hexon protein. The hexon gene encodes this crucial protein, which plays an indispensable role in the assembly and stability of the viral particle.

Hosts and Associated Diseases:

EDSV's primary targets are avian species, with chickens being particularly susceptible. When EDSV infects a flock, it brings about a condition known as Egg Drop Syndrome. The hallmark of this syndrome is a sudden and drastic drop in egg production, which can be financially devastating to poultry farmers. In addition to decreased egg production, affected birds may also exhibit other clinical signs, including poor eggshell quality, the production of soft-shelled or shell-less eggs, respiratory distress, and gastrointestinal symptoms. Egg Drop Syndrome represents a substantial challenge to the poultry industry worldwide, making the detection and management of EDSV of utmost importance.

Pathogen Classification:

In the realm of microbiology, EDSV is classified as a DNA virus. More specifically, it is categorized within the Aviadenovirus genus, which is a subset of the Adenoviridae family. Adenoviruses, as a group, are known for their double-stranded DNA genomes and their ability to infect a wide range of hosts, including humans, though EDSV is a poultry-specific strain with no reported zoonotic potential.

Diagnostic Methods:

Accurate and timely detection of EDSV is paramount for preventing and managing outbreaks. Several diagnostic methods are employed for this purpose, targeting the viral DNA. These methods include:

Polymerase Chain Reaction (PCR): PCR assays are designed to amplify specific regions of the EDSV genome, with common target genes being the hexon gene and the fiber gene. These tests offer high sensitivity and specificity, making them a preferred choice for EDSV detection.

Loop-Mediated Isothermal Amplification (LAMP): LAMP assays offer a rapid and specific means of detecting EDSV nucleic acids. They are particularly useful for on-site or point-of-care testing.

Virus Isolation: Virus isolation involves the extraction and culturing of the virus from clinical samples. This method allows for the definitive confirmation of EDSV presence through the observation of characteristic cytopathic effects in cell cultures.

Serological Tests: Enzyme-Linked Immunosorbent Assays (ELISAs) are widely used to detect antibodies against EDSV in serum samples. Serological testing helps in assessing the extent of exposure within a flock.

Immunofluorescence Assays: These assays employ specific antibodies to identify the presence of EDSV in infected tissues or cells, allowing for direct visualization of the virus.

In summary, EDSV, or Egg Drop Syndrome Virus, is a highly specialized pathogen within the Aviadenovirus genus that poses a significant threat to poultry health and the poultry industry as a whole. Understanding its characteristics, structure, host range, associated diseases, and diagnostic methods is crucial for efficient management and containment. Through the use of advanced diagnostic techniques such as PCR, LAMP, and serological assays, veterinarians and poultry farmers can rapidly identify and respond to EDSV outbreaks, minimizing economic losses and ensuring the health of avian populations.

In the constantly evolving field of veterinary medicine and poultry health, ongoing research and vigilance in monitoring EDSV are essential to developing improved diagnostics and preventive strategies. Additionally, ensuring biosecurity measures within poultry farms remains paramount in preventing the introduction and spread of this and other avian pathogens.

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