Avian Paramyxovirus Type 1/Newcastle Disease Virus antibody and antigen (recombinant protein)

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Diagnostic anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease Newcastle disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P168-Ag01	Recombinant Avian Paramyxovirus Type 1/Newcastle Disease Virus protein	$3090.00
GMP-VT-P168-Ab01	Anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P168-Ab02	Anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P168-Ag01
Product Name	Recombinant Avian Paramyxovirus Type 1/Newcastle Disease Virus protein
Pathogen	Avian Paramyxovirus Type 1/Newcastle Disease Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian Paramyxovirus Type 1/Newcastle Disease Virus level test of animal Avian/Bird/Poultry infectious disease with Newcastle disease.
Tag	His
Product description	Recombinant Avian Paramyxovirus Type 1/Newcastle Disease Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P168-Ab01,GMP-VT-P168-Ab02
Pathogen	Avian Paramyxovirus Type 1/Newcastle Disease Virus
Product Name	Anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Avian Paramyxovirus Type 1/Newcastle Disease Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus antibodies in Avian Paramyxovirus Type 1/Newcastle Disease Virus level test of animal Avian/Bird/Poultry infectious disease with Newcastle disease.
Product description	Anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian Paramyxovirus Type 1/Newcastle Disease Virus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Avian Paramyxovirus Type 1, more commonly referred to as the Newcastle Disease Virus (NDV), is a highly contagious virus that primarily affects birds. NDV belongs to the Paramyxoviridae family, which is a group of enveloped RNA viruses that cause a variety of diseases in both humans and animals. NDV is a single-stranded negative-sense RNA virus, meaning that its genetic material is composed of a single strand of RNA that is complementary to the viral messenger RNA (mRNA).

The virus is known to infect both domestic and wild birds, including chickens, turkeys, ducks, pigeons, and ostriches. NDV can be found worldwide, with outbreaks occurring in various countries across Asia, Africa, Europe, and the Americas. The virus can cause respiratory disease, digestive disorders, and neurological symptoms in infected birds.

The pathogenesis of NDV varies depending on the virulence of the strain, host susceptibility, and the route of infection. NDV infections can range from mild respiratory symptoms to severe systemic infections leading to high mortality rates among infected birds. The disease is of great economic importance in the poultry industry, causing significant losses in productivity and trade restrictions in affected regions.

NDV is transmitted through direct contact with infected birds, bodily fluids, contaminated feed, water, and equipment. The virus can survive in the environment for several weeks, making it easy to spread through indirect transmission. Additionally, NDV can be transmitted through inhalation of aerosolized virus particles, making it a significant concern in crowded bird populations.

Diagnostic methods for NDV include virus isolation, which involves growing the virus in cultured cells or embryonated eggs and observing the characteristic cytopathic changes. Serological testing using ELISA and virus-neutralization assays can detect the presence of specific antibodies against NDV in blood samples. RT-PCR can detect viral RNA in clinical samples, such as swabs from the respiratory tract or cloaca, and is a more rapid and sensitive method of detection compared to virus isolation. Immunohistochemistry and fluorescent antibody testing can also be used to detect viral antigens in tissue samples.

Prevention and control measures for NDV include vaccination, biosecurity measures, and disease surveillance. Vaccination of poultry flocks is the most effective way to prevent and control NDV outbreaks. Biosecurity measures, such as quarantine, disinfection, and controlled access to bird populations, can help limit the spread of the virus. Disease surveillance programs that monitor the status of local bird populations and detect early signs of infection are also essential in preventing the spread of NDV.

In conclusion, Newcastle Disease Virus (NDV) is a highly contagious virus that primarily affects birds, causing significant economic losses in the poultry industry as well as posing a threat to human health. Early detection through diagnostic methods and implementation of prevention and control measures, including vaccination and stringent biosecurity measures, can help reduce the impact of NDV on bird populations and limit the spread of the disease.

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