Equine/Horse infectious anemia Virus antibody and antigen (recombinant protein)

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Diagnostic anti-Equine/Horse infectious anemia Virus antibodies pairs and antigen for animal health (animal Equine/Horse infectious disease Equine/Horse infectious anemia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P139-Ag01	Recombinant Equine/Horse infectious anemia Virus protein	$3090.00
GMP-VT-P139-Ab01	Anti-Equine/Horse infectious anemia Virus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P139-Ab02	Anti-Equine/Horse infectious anemia Virus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P139-Ag01
Product Name	Recombinant Equine/Horse infectious anemia Virus protein
Pathogen	Equine/Horse infectious anemia Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine/Horse infectious anemia Virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Equine/Horse infectious anemia Virus level test of animal Equine/Horse infectious disease with Equine/Horse infectious anemia.
Tag	His
Product description	Recombinant Equine/Horse infectious anemia Virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P139-Ab01,GMP-VT-P139-Ab02
Pathogen	Equine/Horse infectious anemia Virus
Product Name	Anti-Equine/Horse infectious anemia Virus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine/Horse infectious anemia Virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine/Horse infectious anemia Virus antibodies in Equine/Horse infectious anemia Virus level test of animal Equine/Horse infectious disease with Equine/Horse infectious anemia.
Product description	Anti-Equine/Horse infectious anemia Virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine/Horse infectious anemia Virus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Equine infectious anemia virus (EIAV), also known as horse infectious anemia virus, is a retrovirus that causes equine infectious anemia (EIA) in horses, mules, and donkeys. The virus is primarily transmitted through blood-to-blood contact, such as from biting insects or contaminated needles. While some horses may show no symptoms, they can still serve as carriers of the virus and spread it to other horses.

EIAV is classified as a type of RNA virus called a retrovirus. Retroviruses use reverse transcriptase to produce DNA from its RNA genome for replication within host cells. The main gene responsible for EIAV's structure and function is the env gene, which codes for envelope glycoproteins crucial for viral entry into host cells. Among these glycoproteins, glycoprotein 90 (gp90) plays a crucial role in mediating attachment and entry into host cells.

When horses are infected with EIAV, they may develop acute or chronic illness. Symptoms of EIA include lethargy, weight loss, fever, swelling, and anemia. Infected horses may also experience depression, jaundice, and hemorrhaging. However, some infected horses may not show any symptoms at all.

Diagnosing EIAV requires specialized testing using serological methods or Polymerase Chain Reaction (PCR). In the serological testing method, the agar gel immunodiffusion (AGID) test is used to detect antibodies against the virus present in blood samples. This test is based on the principle of antigen-antibody reactions where antibodies present in the sample react with specific antigens to form visible bands. However, this test does not detect the virus directly, but rather the antibodies produced by the horse in response to the virus.

PCR testing is another method used to detect EIAV. PCR is a highly sensitive molecular biology technique used to amplify and detect specific DNA or RNA sequences. This test can directly detect viral RNA or DNA in blood samples by targeting viral env genes or their corresponding proteins. PCR testing is considered more sensitive and specific than the AGID test, but requires specialized laboratory equipment and trained personnel.

There is currently no vaccine available for EIAV, and treatment options are limited. Infected horses may require supportive care and management to minimize symptoms. However, due to the highly contagious nature of the virus, infected horses are typically euthanized to prevent transmission to other horses.

In conclusion, EIAV is a serious viral infection that affects horses, mules, and donkeys. It can cause acute or chronic illness with a range of symptoms and can be transmitted through blood-to-blood contact. Diagnosis of EIAV requires specialized testing using serological methods or PCR. While there is no vaccine available for EIAV, prevention measures such as proper management practices and regular screening can help reduce the spread of the virus within horse populations.

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