Campylobacter fetus antibody and antigen (recombinant protein)

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Diagnostic anti-Campylobacter fetus antibodies pairs and antigen for animal health (animal Ovines/Sheep, infectious disease Campylobacteriosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P078-Ag01	Recombinant Campylobacter fetus protein	$3090.00
GMP-VT-P078-Ab01	Anti-Campylobacter fetus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P078-Ab02	Anti-Campylobacter fetus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P078-Ag01
Product Name	Recombinant Campylobacter fetus protein
Pathogen	Campylobacter fetus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Campylobacter fetus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Campylobacter fetus level test of animal Ovines/Sheep, infectious disease with Campylobacteriosis.
Tag	His
Product description	Recombinant Campylobacter fetus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P078-Ab01,GMP-VT-P078-Ab02
Pathogen	Campylobacter fetus
Product Name	Anti-Campylobacter fetus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Campylobacter fetus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Campylobacter fetus antibodies in Campylobacter fetus level test of animal Ovines/Sheep, infectious disease with Campylobacteriosis.
Product description	Anti-Campylobacter fetus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Campylobacter fetus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

Campylobacter fetus is a bacterial pathogen that belongs to the Campylobacteraceae family and is predominantly associated with ruminant animals such as cattle, sheep, and goats. This pathogen causes reproductive failure, infertility, and abortions in these animals. In addition, it can also cause human infections, resulting in acute gastroenteritis, septicemia, and other severe clinical conditions.

The pathogen's genome consists of several genes that contribute to its virulence, resistance to environmental stresses, and adaptation to different hosts. One of the most significant virulence factors of Campylobacter fetus is its flagella that facilitate motility and adherence to host cells. The flaA gene encoding this factor is commonly used in diagnostic methods for Campylobacter fetus.

The pathogen's structure comprises several proteins and other molecular components that affect its pathogenicity and virulence. For instance, CadF is another virulence factor found on the surface of Campylobacter fetus that plays a critical role in adherence to host cells. This protein binds to fibronectin and laminin present on the host's surfaces, enabling the bacterium to colonize and persist in the host.

The hosts infected by Campylobacter fetus include mainly ruminant animals, but humans can also become infected through the consumption of contaminated food or water, contact with infected animals, or environmental exposure. Human infections caused by the pathogen are generally self-limiting, but individuals with certain risk factors such as immunocompromised status or pre-existing medical conditions may develop severe illnesses that require prompt medical attention.

Several diagnostic methods are available to detect Campylobacter fetus, including culture-based approaches, PCR, ELISA, and nucleic acid hybridization. Culture-based techniques involve the isolation of the pathogen from clinical samples using selective culture media, after which the pathogen can be identified through its typical morphology, biochemical properties, and antimicrobial susceptibility patterns.

PCR is a molecular technique that amplifies the flaA gene of Campylobacter fetus, enabling its detection even in small amounts of DNA. This method is highly specific and sensitive, making it ideal for detecting the pathogen in clinical and environmental samples.

ELISA is an immunological assay that detects specific antibodies against Campylobacter fetus in serum or other body fluids. This technique is useful in identifying recently infected individuals or those with previous exposure to the pathogen.

Nucleic acid hybridization is a method that uses complementary nucleic acid probes to identify specific DNA sequences of Campylobacter fetus in clinical and environmental samples. This technique is useful in identifying the pathogen's presence in complex samples containing multiple microbial species.

In conclusion, Campylobacter fetus is a bacterial pathogen commonly associated with ruminant animals that can cause severe clinical conditions in both animals and humans. The pathogen's virulence factors such as flagella and CadF protein play essential roles in colonization and persistence in the host. Several diagnostic methods are available for detecting Campylobacter fetus, including culture-based approaches, PCR, ELISA, and nucleic acid hybridization, each with unique advantages and applications in clinical and environmental settings.

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