Rabies virus antibody and antigen (recombinant protein)

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Diagnostic anti-Rabies virus antibodies pairs and antigen for animal health (animal Dog/Canine infectious disease Rabies) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P018-Ag01	Recombinant Rabies virus protein	$3090.00
GMP-VT-P018-Ab01	Anti-Rabies virus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P018-Ab02	Anti-Rabies virus mouse monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P018-Ag01
Product Name	Recombinant Rabies virus protein
Pathogen	Rabies virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Rabies virus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Rabies virus level test of animal Dog/Canine infectious disease with Rabies.
Tag	His
Product description	Recombinant Rabies virus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P018-Ab01,GMP-VT-P018-Ab02
Pathogen	Rabies virus
Product Name	Anti-Rabies virus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Rabies virus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rabies virus antibodies in Rabies virus level test of animal Dog/Canine infectious disease with Rabies.
Product description	Anti-Rabies virus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Rabies virus antibodies./td>
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen

The Rabies virus is a zoonotic virus that causes the infectious disease known as rabies. The virus primarily infects members of the order Carnivora, such as dogs, cats, foxes, and raccoons, but also infects bats, skunks, and other mammals. Humans can also become infected with the Rabies virus through contact with saliva or other bodily fluids of an infected animal.

The Rabies virus belongs to the family Rhabdoviridae, which is a group of negative-sense single-stranded RNA viruses. The virus is bullet-shaped and is approximately 75 nanometers long and 180 nanometers wide. The virus contains five structural proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and the RNA-dependent RNA polymerase (L). The G protein is responsible for viral attachment and entry into host cells, while the N protein encapsidates the viral RNA genome.

Once the Rabies virus enters the body, it travels to the brain via the nervous system. The virus replicates in motor neurons and travels along axons from the peripheral nervous system to the brain, where it causes acute encephalitis. This results in a series of symptoms that include fever, headache, fatigue, muscle weakness, and irritability. In severe cases, the patient may experience seizures, hallucinations, difficulty breathing, paralysis, and ultimately death.

Diagnosis of Rabies virus infection is typically performed using tests that detect the virus directly or measure the host's immune response to the virus. The direct fluorescent antibody test (dFA) is one such test that detects the presence of Rabies virus antigens in tissue samples. The isolation of the virus in cell culture is another method for Rabies virus detection. Reverse transcription polymerase chain reaction (RT-PCR) is a molecular method that can detect the viral RNA genome in tissue samples. Serological tests, such as the indirect fluorescent antibody test (IFAT) and the enzyme-linked immunosorbent assay (ELISA), measure the presence of antibodies produced by the host's immune system in response to the virus.

Prevention of Rabies virus infection primarily involves vaccination of animals and prompt treatment of infected individuals. Inactivated or recombinant vaccines against the virus are available for use in animals. Post-exposure prophylaxis (PEP) is a series of injections that can prevent the onset of Rabies symptoms in humans who have been exposed to the virus. The World Health Organization recommends PEP for individuals who have had contact with an animal suspected of having Rabies.

In conclusion, the Rabies virus is a serious pathogen that causes fatal encephalitis in mammals, including humans. The virus is transmitted through contact with the saliva of an infected animal and travels along the nervous system to the brain, where it causes severe neurological symptoms. Accurate and timely diagnosis of Rabies virus infection by using various diagnostic methods is crucial for effective prevention and control of this disease.

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