Bacitracin(BCT) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Bacitracin(BCT) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Bacitracin(BCT)

OVA-Bacitracin(BCT)

Anti-Bacitracin(BCT) mouse monoclonal antibody

Anti-Bacitracin(BCT) human monoclonal antibody

Reference

Validation Data

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Biomarker Information

Understanding Bacitracin (BCT) and its Significance in Veterinary Drug Residues and Additives:

Bacitracin (BCT), a polypeptide antibiotic originating from Bacillus subtilis, plays a pivotal role in veterinary medicine. Its multifaceted functions encompass antibiotic therapy, growth promotion, and safeguarding the integrity of animal-derived products.

a. Antibiotic Efficacy: Bacitracin serves as a potent antibiotic agent against specific Gram-positive bacterial strains. In the veterinary realm, it aids in the treatment and prevention of bacterial infections in various animal species, especially in livestock. This antibiotic exerts its antimicrobial action by interfering with the synthesis of the bacterial cell wall, making it a valuable tool in the veterinarian's arsenal against susceptible pathogens. It is particularly effective against Streptococci and Staphylococci infections commonly found in animals.

b. Growth Enhancement: Bacitracin, under sub-therapeutic administration, has been employed as a growth promoter in animal feed, notably in poultry and swine farming. However, certain regions have curtailed or banned its use due to concerns regarding antibiotic resistance and residues in animal products. When used at sub-therapeutic levels, Bacitracin has been shown to improve feed efficiency and weight gain in animals. It achieves this by promoting a healthier gut microbiota and reducing the prevalence of certain bacterial infections in the intestines. Nonetheless, its use for growth promotion has been a subject of debate due to concerns about antibiotic resistance development.

c. Residue Management: The utilization of Bacitracin in veterinary medicine raises concerns about residual presence in animal-derived products, such as meat and milk. The monitoring and control of Bacitracin residues are paramount for food safety and compliance with regulatory thresholds. Residues of Bacitracin can be found in various animal-derived products when the antibiotic is used in animal husbandry. These residues can pose health risks to consumers, especially when they exceed acceptable limits. Therefore, accurate residue measurement is essential to ensure that animal products intended for human consumption remain safe and compliant with regulatory standards.

d. Regulatory Adherence: Rigorous regulatory standards are in place across nations to oversee veterinary drug usage, including Bacitracin. These regulations stipulate Maximum Residue Limits (MRLs) to ensure that animal products intended for human consumption remain within safe Bacitracin residue levels. To achieve compliance, analytical techniques, involving anti-Bacitracin antibodies and competitive antigens, are deployed for residue measurement. Governments and international organizations have established Maximum Residue Limits (MRLs) to ensure that animal products do not contain harmful levels of Bacitracin residues. These limits are set based on scientific evidence and risk assessments to protect human health. Analytical techniques such as enzyme-linked immunosorbent assays (ELISA) and liquid chromatography-mass spectrometry (LC-MS) are used to measure Bacitracin residues in animal products.

e. Quality Assurance: Beyond regulatory considerations, accurate Bacitracin measurements are imperative for quality assurance in the production of animal feed and pharmaceuticals. The precise quantification of Bacitracin concentrations in formulations is vital to maintain the efficacy of veterinary drugs and additives. For pharmaceutical and animal feed manufacturers, quality control is paramount. Ensuring that the stated amount of Bacitracin is present in products is essential to deliver the expected therapeutic benefits and performance in animals. Quality assurance processes involve meticulous testing and measurement to guarantee the accuracy of Bacitracin concentrations in the formulations.

2. The Significance of Bacitracin (BCT) Measurement:

The quantification of Bacitracin levels holds profound importance for various scientific, regulatory, and health-related reasons:

a. Regulatory Adherence: Stricter regulatory compliance necessitates the precise measurement of Bacitracin levels in animal products. These measurements are essential to meet regulatory requirements and ensure that human health is protected from excessive Bacitracin residues in food. Regulatory bodies, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have established MRLs for Bacitracin in various animal products. Ensuring that products meet these limits is crucial to adhere to regulations and protect public health.

b. Food Safety Assurance: Monitoring Bacitracin levels guarantees the safety of food products originating from animals treated with this antibiotic. Elevated Bacitracin residues pose health risks to consumers and can be avoided through vigilant measurement. Ensuring the safety of the food supply is a primary concern for both regulatory agencies and consumers. Accurate measurement of Bacitracin residues helps to maintain food safety by preventing the presence of harmful levels of the antibiotic in meat, milk, and other animal-derived products.

c. Antibiotic Resistance Mitigation: The careful measurement of Bacitracin usage and residues is an effective strategy in mitigating the development of antibiotic resistance, a global health concern arising from the inappropriate use of antibiotics in veterinary medicine. The misuse and overuse of antibiotics in veterinary medicine can contribute to the development of antibiotic-resistant bacteria. By measuring Bacitracin usage and residues, veterinarians and researchers can better understand how this antibiotic is impacting bacterial populations and work towards more responsible antibiotic use to mitigate resistance.

d. Quality Control and Assurance: Accurate Bacitracin measurements are fundamental in maintaining the quality and efficacy of veterinary drug formulations and animal feed additives, ensuring that these products function optimally in animal healthcare. The efficacy of veterinary drug formulations and animal feed additives is closely tied to the accuracy of Bacitracin concentrations. Ensuring that the stated amount of Bacitracin is present in these products is essential for their intended therapeutic and performance benefits. Quality control and assurance processes are essential to confirm the accuracy of Bacitracin measurements.

e. Research Advancement: Bacitracin measurement is invaluable in advancing scientific research, enabling pharmacokinetic studies, safety assessments, and the development of enhanced veterinary formulations. It serves as the cornerstone for the continued improvement of veterinary medicine practices. Scientific research in veterinary medicine relies on accurate measurements of Bacitracin to understand its pharmacokinetics, safety, and effectiveness. This research contributes to the development of improved veterinary formulations and practices, ultimately benefiting animal health and food safety.

In summary, Bacitracin measurement holds paramount significance in veterinary medicine, with implications spanning food safety, regulatory compliance, antibiotic stewardship, and the overall quality and effectiveness of veterinary products. Accurate measurement techniques and adherence to regulatory standards are crucial in ensuring the responsible and effective use of Bacitracin in veterinary applications, which ultimately has a significant impact on animal and human health.

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