Cephalosporin(CEP) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Cephalosporin(CEP) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-SMT-66-1	1. BSA-Cephalosporin(CEP) 2. Anti-Cephalosporin(CEP) mouse monoclonal antibody	$2709.00
GMP-SMT-66-2	1. OVA-Cephalosporin(CEP) 2. Anti-Cephalosporin(CEP) mouse monoclonal antibody	$2709.00
GMP-SMT-66-3	1. BSA-Cephalosporin(CEP) 2. Anti-Cephalosporin(CEP) human monoclonal antibody	$2709.00
GMP-SMT-66-4	1. OVA-Cephalosporin(CEP) 2. Anti-Cephalosporin(CEP) human monoclonal antibody	$2709.00
GMP-SMT-66-5	1. BSA-Cephalosporin(CEP) 2. Recombinant beta-lactams sensor protein	$2709.00
GMP-SMT-66-6	1. OVA-Cephalosporin(CEP) 2. Recombinant beta-lactams sensor protein	$2709.00
GMP-SMT-66-Ag-1	BSA-Cephalosporin(CEP)	$756.00
GMP-SMT-66-Ag-2	OVA-Cephalosporin(CEP)	$756.00
GMP-SMT-66-Ab-1	Anti-Cephalosporin(CEP) mouse monoclonal antibody	$1953.00
GMP-SMT-66-Ab-2	Anti-Cephalosporin(CEP) human monoclonal antibody	$1953.00
GMP-SMT-sensor-1	Recombinant beta-lactams sensor protein	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

BSA-Cephalosporin(CEP)

Cat No.	GMP-SMT-66-Ag-1
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Cephalosporin(CEP) with anti-Hapten antibody. The hapten hapten-carrier conjugates BSA-Cephalosporin(CEP) had been validated with our anti-Hapten antibody Anti-Cephalosporin(CEP) mouse monoclonal antibody via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

OVA-Cephalosporin(CEP)

Cat No.	GMP-SMT-66-Ag-2
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description	Competitive immunoassay-validated hapten-carrier conjugates OVA-Cephalosporin(CEP) with anti-Hapten antibody. The hapten hapten-carrier conjugates OVA-Cephalosporin(CEP) had been validated with our anti-Hapten antibody Anti-Cephalosporin(CEP) mouse monoclonal antibody via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-Cephalosporin(CEP) mouse monoclonal antibody

Cat No.	GMP-SMT-66-Ab-1
Host of Antibody	Mouse IgG
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb)	1-2
Products description	The anti-Hapten antibody against hapten Cephalosporin(CEP) had been validated with our hapten hapten-carrier conjugates BSA-Cephalosporin(CEP) via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-Cephalosporin(CEP) human monoclonal antibody

Cat No.	GMP-SMT-66-Ab-2
Host of Antibody	Human IgG1
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb)	1-2
Products description	The anti-Hapten antibody against hapten Cephalosporin(CEP) had been validated with our hapten hapten-carrier conjugates BSA-Cephalosporin(CEP) via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Recombinant beta-lactams sensor protein

Cat No.	GMP-SMT-Sensor-1
Antigen & Antibody Name	Recombinant beta-lactams sensor protein
Expression platform	mammalian cell
Isotypes	Recombinant protein
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
Tag	mFc
Products description	Recombinant beta-lactams sensor protein was expressed in mammalian cell expression system with mFc tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Antibody in Elisa, Competitive ELISA, lateral-flow tests, and other immunoassays
Formulation	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Application development scientists of GDU (GeneMedi Diagnostics Unit) have generated and optimized the beta-lactams sensor protein with a larger linear range and better sensitivity against the beta-lactams. We tested 24 kinds of beta-lactams. Below is the competitive ELISA data of GeneMedi’s optimized beta-lactams sensor recombinant protein. For Ampicillin EC50 = 0.53 ng/ml (ppb); For Penicillin G, EC50 = 0.19 ng/ml (ppb). Our Recombinant beta-lactams sensor protein has obtained good performances, such as the stability and sensitivity.


Figure 1. GeneMedi's Recombinant beta-lactams sensor protein was validated to detect the beta-lactams (Ampicillin, Penicillin G, Cequinome, Cefapirin, Cephalexin, Ceftiofur) in ELISA.

Beta-lactams	Cross-Reactivity	Beta-lactams	Cross-Reactivity
Penicillin G	Y	Nafcillin	Y
Ampicillin	Y	Cephalothin	Y
Ceftiofur	Y	Cefapirin	Y
Cefquinome	Y	Cefoperazone	Y
Cephalosporin	Y	Cefotaxime	Y
Cephalexin	Y	Cefalotin	Y
Benzylpenicillin	Y	Cefuroxime	Y
Penicillin V	Y	Cefaclor	Y
Amoxicillin	Y	Ceftriaxone	Y
Oxacillin	Y	Cefamandole	Y
Cloxacillin	Y	Moxalactam	Y
Dicloxacillin	Y	Meropenem	Y
Kanamycin (Negative Control)	N	Tetracycline (Negative Control)	N

Table1. GeneMedi's Recombinant beta-lactams sensor protein can detect 24 kinds of beta-lactams with high sensitivity.

Click to get more Data / Case study about the product.

Biomarker Information

Cephalosporin (CEP): A Comprehensive Insight

Cephalosporin (CEP) constitutes a class of small molecules with significant relevance in the domain of veterinary pharmacology. These compounds, belonging to the beta-lactam antibiotic family, exhibit structural similarities to penicillin and play a pivotal role in the management of bacterial infections in animals. Their wide-ranging antibacterial efficacy has established Cephalosporins as indispensable components of veterinary healthcare, ensuring the well-being of both livestock and companion animals through the effective control of bacterial diseases.

Role in Veterinary Drug Residues and Additives (Serial Number 1):

In the context of veterinary drug residues and additives, Cephalosporin assumes a critical role, warranting an in-depth examination. When employed for therapeutic purposes, Cephalosporins have the potential to leave residues in animal-derived products, including meat, milk, and eggs. The inadvertent presence of Cephalosporin residues in these food items carries multifaceted implications.

Firstly, from a consumer safety perspective (Serial Number 1a), the accumulation of Cephalosporin residues in food products could pose health risks to individuals who consume these products. Therefore, meticulous measurement and control of CEP levels are vital to ensure that food products meet stringent safety standards and do not contain harmful residues.

Secondly, and of equal concern, is the matter of antibiotic resistance (Serial Number 1b). The global health community is grappling with the escalating issue of antibiotic resistance, and the excessive use of antibiotics, including Cephalosporins, in animals can contribute to this problem. Careful monitoring of CEP levels helps regulate the use of these antibiotics, a critical aspect of the broader global effort to combat antibiotic resistance.

Furthermore, regulatory compliance (Serial Number 1c) is an essential facet of the veterinary industry. Many countries have established strict regulations governing the use of antibiotics in animal husbandry. Precise measurement of CEP levels is imperative for compliance, ensuring that veterinary practitioners and pharmaceutical companies adhere to these regulations, thereby avoiding legal consequences and penalties.

Quality assurance (Serial Number 1d) is an additional dimension where CEP measurement holds significance. For pharmaceutical manufacturers and veterinarians, the accurate measurement of CEP levels is pivotal to quality assurance. It guarantees the potency and effectiveness of Cephalosporin-based drugs, and it confirms that these products meet the specified criteria for animal healthcare, underlining their reliability and performance.

In the realm of scientific research and development (Serial Number 1e), CEP measurement plays an integral role. Researchers and scientists frequently require precise CEP level measurements for various studies encompassing veterinary medicine, antibiotic research, and drug development. Such measurements not only contribute to the advancement of the field but also facilitate the development of improved treatment options for animals.

The Significance of Measuring Cephalosporin (CEP) (Serial Number 2):

The importance of measuring Cephalosporin (CEP) levels extends across a spectrum of domains and entails several facets:

a. Food Safety (Serial Number 2a): Rigorous measurement of CEP levels assures the safety of animal-derived products, preventing potential health hazards linked to Cephalosporin residues in consumables. Consumers can rest assured that their food is free from harmful residues.

b. Antibiotic Resistance (Serial Number 2b): In the context of global concerns surrounding antibiotic resistance, accurate measurement of CEP levels is a proactive measure. It assists in the judicious use of these antibiotics in veterinary medicine, making a significant contribution to the ongoing battle against the development of antibiotic resistance.

c. Regulatory Compliance (Serial Number 2c): Adherence to stringent regulations regarding antibiotic use in animal husbandry is facilitated by precise CEP level measurements. By ensuring compliance, veterinary practitioners and pharmaceutical manufacturers avoid legal repercussions, safeguarding their operations and reputations.

d. Quality Assurance (Serial Number 2d): For pharmaceutical companies and veterinarians, accurate CEP measurement is indispensable for quality assurance. It confirms the effectiveness and potency of Cephalosporin-based drugs, essential for maintaining the health and well-being of animals.

e. Research and Development (Serial Number 2e): Scientific research in the field of veterinary medicine, antibiotic efficacy, and drug development heavily relies on precise CEP level measurements. These measurements are pivotal for advancing the field, expanding our knowledge, and ultimately developing superior treatment options for animals.

In essence, the meticulous measurement of Cephalosporin (CEP) levels is a cornerstone of veterinary pharmacology and food safety. It serves to protect the health of both animals and humans by ensuring that animal-derived products are free from harmful residues. Simultaneously, it plays a pivotal role in combatting antibiotic resistance, facilitating regulatory compliance, guaranteeing product quality, and advancing scientific research. CEP measurement is not just a technical requirement but a multidimensional process with far-reaching implications for the veterinary and pharmaceutical industries.

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