Danofloxacin antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Danofloxacin antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Danofloxacin

OVA-Danofloxacin

Anti-Danofloxacin mouse monoclonal antibody

Anti-Danofloxacin human monoclonal antibody

Reference

Validation Data

Click to get more Data / Case study about the product.

Biomarker Information

1. Danofloxacin in Veterinary Medicine: A Comprehensive Overview

Danofloxacin, an integral member of the fluoroquinolone class of antibiotics, stands as a cornerstone in modern veterinary medicine. Its significance emanates from its potent antimicrobial properties, particularly against gram-negative bacteria, making it a critical tool in the armamentarium against infectious diseases in livestock. Developed specifically for veterinary applications, Danofloxacin addresses a diverse array of bacterial infections in animals, with primary usage observed in cattle, swine, and poultry.

1.1 Mechanism of Action and Spectrum of Activity:

At its core, Danofloxacin operates by inhibiting the bacterial DNA gyrase and topoisomerase IV enzymes, essential for DNA replication and repair. This interference hampers bacterial growth and ultimately leads to bacterial cell death. Its broad-spectrum activity encompasses various gram-negative organisms, notably strains of Escherichia coli, Pasteurella multocida, and Mannheimia haemolytica, frequently implicated in respiratory and enteric infections in animals. This versatility positions Danofloxacin as a crucial therapeutic agent, especially in scenarios where rapid and effective treatment is imperative to prevent economic losses in the agricultural sector.

1.2 Role in Veterinary Drug Residues and Additives:

The administration of Danofloxacin to livestock necessitates a meticulous understanding of its pharmacokinetics and potential residues in animal-derived products. Post-administration, trace amounts of Danofloxacin can persist in edible tissues such as meat and milk. Consequently, meticulous monitoring of these residues becomes indispensable, ensuring compliance with stringent food safety regulations. These regulations, set forth by regulatory bodies like the Food and Drug Administration (FDA) and the United States Department of Agriculture (USDA), establish Maximum Residue Limits (MRLs) that must not be exceeded to guarantee consumer safety and maintain the integrity of the food supply chain.

1.3 Pharmacokinetics and Residual Traces:

Danofloxacin's pharmacokinetic profile further underscores the need for precise monitoring. The antibiotic exhibits favorable bioavailability, ensuring efficient absorption and distribution within the animal's body. However, this efficient absorption can also lead to residual traces in edible tissues. Understanding the pharmacokinetic parameters, including absorption rates, distribution, metabolism, and excretion, is pivotal. Such comprehension informs withdrawal periods – the duration required post-treatment for the residue levels to fall within permissible limits, ensuring that animal-derived products are safe for human consumption.

2. Significance of Measuring Danofloxacin: Ensuring Safety, Compliance, and Quality

2.1 Food Safety Assurance:

Consumer safety lies at the heart of monitoring Danofloxacin residues in animal-derived products. Accurate measurement is pivotal in guaranteeing that the food supply chain remains uncontaminated, devoid of antibiotic residues that could pose potential health risks to consumers. Responsible practices in veterinary medicine, coupled with rigorous testing methodologies, are paramount to achieving this objective. Continuous surveillance of residue levels offers valuable insights into the safety quotient of consumables, allowing timely interventions if deviations from established safety standards are detected.

2.2 Regulatory Compliance:

Regulatory bodies, such as the FDA and USDA, meticulously delineate MRLs to ensure the harmonious coexistence of veterinary practices and public health. Measuring Danofloxacin levels is not merely a recommendation but a regulatory imperative. Adherence to these stipulated limits is mandatory, and non-compliance can lead to severe repercussions, including legal consequences and restrictions on the sale of animal products. The meticulous measurement of Danofloxacin residues is, therefore, a non-negotiable aspect of veterinary practices and food production protocols.

2.3 Mitigating Antibiotic Resistance:

The emergence of antibiotic-resistant bacterial strains poses a significant threat to global public health. Danofloxacin, when misused or overused, can contribute to the development of these resistant strains. Monitoring its levels in animal tissues is a strategic measure to curb this worrisome trend. By ensuring that Danofloxacin is administered in accordance with prescribed guidelines and withdrawal periods, the risk of antibiotic resistance is mitigated. Through regular measurements and subsequent interventions, veterinarians and researchers contribute to the broader global effort against antimicrobial resistance.

2.4 Quality Control in Biopharmaceuticals:

Beyond its significance in veterinary medicine, Danofloxacin's precise measurement holds pivotal importance in the realm of biopharmaceuticals. Biotechnology companies engaged in the production of small molecule antibodies and competitive antigens rely on stringent quality control measures. Accurate quantification of Danofloxacin is indispensable during the production and validation processes of these biopharmaceutical products. Ensuring that these products are free from unintended residues, including Danofloxacin, is fundamental to their efficacy and safety profiles. These meticulous quality control measures not only align with regulatory guidelines but also underscore the ethical responsibility of the biopharmaceutical industry towards end-users and consumers.

Conclusion:

In the intricate tapestry of veterinary medicine and biopharmaceuticals, Danofloxacin assumes multifaceted significance. From its role as a potent antibiotic combating infectious diseases in animals to its impact on food safety, regulatory compliance, and the fight against antibiotic resistance, its nuanced understanding and precise measurement are imperative. By delving into the intricate pharmacokinetics, residual traces, and the broader implications of its usage, the veterinary community and biopharmaceutical industry jointly uphold the pillars of animal health, public safety, and product quality, thus shaping a future where the delicate balance between human intervention and nature's complexities is meticulously preserved.I'm glad you found the information helpful! If you have any more questions or if there's anything else I can assist you with, feel free to ask.

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