Levamisole antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Levamisole antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Levamisole

OVA-Levamisole

Anti-Levamisole mouse monoclonal antibody

Anti-Levamisole human monoclonal antibody

Reference

Validation Data

Click to get more Data / Case study about the product.

Biomarker Information

1. Levamisole: Role in Veterinary Drug Residues and Additives

1.1 What is Levamisole?

Levamisole is a chiral imidazothiazole derivative with broad-spectrum anthelmintic properties. This synthetic small molecule has found utility in both veterinary and human medicine, owing to its ability to combat parasitic worm infections effectively. Its mechanism of action primarily involves stimulating nicotinic acetylcholine receptors in nematode worms, leading to paralysis and eventual expulsion from the host organism. Levamisole's remarkable efficacy in this regard has made it a valuable tool in the management of parasitic infestations, particularly in the veterinary sector.

1.2 Role in Veterinary Drug Residues and Additives

In the realm of veterinary medicine, Levamisole serves a pivotal role as an anthelmintic agent, primarily in the livestock industry. Cattle and sheep, among other animals, are susceptible to gastrointestinal nematode infestations that can severely impact their health and productivity. Levamisole is administered to these animals either orally or through feed supplementation to combat these parasitic worms. The anthelmintic action of Levamisole is twofold: it paralyzes the worms, rendering them immobile, and subsequently expels them from the host's gastrointestinal tract. This dual mechanism of action is critical in ensuring the well-being of livestock and, by extension, the quality of animal-derived products such as meat and milk.

1.3 Monitoring Levamisole Residues

The administration of Levamisole to livestock necessitates careful monitoring to prevent potential residues in animal-derived products. Elevated residues of Levamisole in food products, including meat and milk, can pose health risks to consumers, and as a result, regulatory bodies have established permissible limits to safeguard public health. Thus, it becomes essential to employ rigorous monitoring and analytical techniques to ensure that Levamisole levels in these products fall within established safety thresholds.

Bioaccumulation, a phenomenon where the chemical accumulates in the tissues of animals over time, is a concern when using anthelmintic agents like Levamisole. This makes the accurate quantification of Levamisole in animal products a critical aspect of food safety management. Monitoring programs are in place to test and verify that these products meet the regulatory standards, ensuring that consumers are protected from potential adverse effects associated with the ingestion of Levamisole residues.

1.4 Role in Biopharmaceutical Applications

Levamisole's significance extends beyond its role in veterinary medicine. In the realm of biopharmaceuticals, Levamisole is harnessed as a valuable tool in the development of antibodies and immunoassays. To create antibodies for the detection and quantification of Levamisole or to conduct research in the pharmaceutical and clinical fields, this small molecule serves as a competitive antigen or immunogen. Conjugates of Levamisole, including hapten-carrier conjugates, BSA-conjugated, or OVA-conjugated forms, are employed to immunize animals, facilitating the production of specific antibodies against Levamisole.

1.5 Significance of Measuring Levamisole

Accurate measurement of Levamisole is paramount for various compelling reasons:

1.5.1 Food Safety and Regulatory Compliance: Monitoring Levamisole levels in animal-derived products is a pivotal component of food safety. Regulatory authorities worldwide have set stringent limits on the acceptable residues of veterinary drugs in food products to ensure consumer safety. By measuring Levamisole, adherence to these regulations is ensured, mitigating potential health hazards associated with its consumption.

1.5.2 Animal Health: Beyond food safety, precise measurement is essential to ensure the well-being of the treated animals. Accurate dosing of Levamisole is critical to the effectiveness of anthelmintic treatment. Maintaining optimal dosing levels prevents the development of drug-resistant parasites, which could have far-reaching consequences for animal health.

1.5.3 Research and Diagnostics: In a biopharmaceutical context, precise measurement of Levamisole is a fundamental requirement for developing sensitive immunoassays, analytical methods, and research tools. Researchers and pharmaceutical companies rely on these tools to detect and quantify Levamisole in various biological samples for a range of scientific investigations. These studies encompass understanding the pharmacokinetics and pharmacodynamics of Levamisole, its effects on biological systems, and its interactions with other molecules.

1.5.4 Antibody Production: Levamisole is indispensable in generating antibodies specific to its structure. This is invaluable in the development of diagnostic assays and research tools, where the production of highly specific antibodies against Levamisole is vital for the accurate detection and quantification of this small molecule.

In conclusion, Levamisole plays a multifaceted role in veterinary medicine, with its primary function as an anthelmintic in livestock. However, its significance transcends the veterinary realm, as it is widely utilized in biopharmaceutical applications for antibody production and scientific research. Accurate measurement of Levamisole is imperative for safeguarding food safety, ensuring compliance with regulations, protecting animal health, and advancing research and diagnostic capabilities in the biopharmaceutical sector.

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