Albendazole metabolite(ABZ) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Albendazole metabolite(ABZ) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Albendazole metabolite(ABZ)

OVA-Albendazole metabolite(ABZ)

Anti-Albendazole metabolite(ABZ) mouse monoclonal antibody

Anti-Albendazole metabolite(ABZ) human monoclonal antibody

Reference

Validation Data

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Biomarker Information

1. Albendazole Metabolite (ABZ):

Albendazole metabolite (ABZ) is a biologically active compound formed through the metabolic processes of Albendazole, a widely utilized anthelmintic drug in veterinary medicine. Understanding the role of ABZ in veterinary drug residues and additives is essential for ensuring the safety of animal-derived products and the effectiveness of parasite control in livestock.

Role in Veterinary Drug Residues and Additives:

1.1 Marker Residue for Albendazole:

ABZ serves as a marker residue for Albendazole, which means that its presence in animal tissues indicates recent or historical use of Albendazole. This marker function is instrumental in monitoring and regulating the application of veterinary drugs to safeguard food safety and to prevent the inclusion of harmful residues in the human food supply. The detection and quantification of ABZ in animal tissues play a crucial role in verifying the appropriate use of Albendazole in livestock.

1.2 Establishment of Withdrawal Periods:

ABZ and its metabolites can persist in animal tissues after Albendazole administration. To ensure that animal products, such as meat, milk, and eggs, are safe for human consumption, withdrawal periods are established. These withdrawal periods are based on the accurate measurement of ABZ levels. They stipulate the minimum time that must elapse between the last Albendazole treatment and the harvest of animal products to ensure that ABZ and its metabolites fall below established safety thresholds. Measuring ABZ concentrations is a fundamental step in determining these withdrawal periods, which vary depending on the species and the specific veterinary drug application.

1.3 International Trade Compliance:

The international trade of animal-derived products is subject to a myriad of regulations and standards, and the presence of ABZ in these products can significantly impact trade relationships. Different countries have distinct regulations and acceptable residue levels, and ABZ levels must comply with these international norms to facilitate the export of livestock and its by-products. Accurate measurement of ABZ is therefore essential to ensure compliance with international standards, avoid trade barriers, and maintain market access for animal products.

1.4 Prevention of Drug Resistance:

The inappropriate or overuse of Albendazole without proper measurement can lead to the development of drug-resistant parasite strains. This is a significant concern in veterinary medicine, as it can render Albendazole and other anthelmintic drugs ineffective in controlling parasitic infections in animals. Monitoring ABZ levels is vital in preventing the evolution of resistance in parasites, thereby ensuring that Albendazole remains an effective treatment option for livestock.

1.5 Analytical Methods for ABZ Measurement:

The precise measurement of ABZ concentrations in animal tissues and products is a multidisciplinary endeavor that involves analytical chemistry, pharmacology, and regulatory sciences. High-performance liquid chromatography (HPLC), mass spectrometry (MS), and enzyme-linked immunosorbent assays (ELISA) are some of the analytical techniques used for ABZ measurement. These methods provide accurate and sensitive quantification of ABZ, allowing for the reliable determination of its presence and concentration in various matrices.

1.6 Monitoring and Reporting:

Veterinary authorities and regulatory agencies play a pivotal role in monitoring and reporting on ABZ residues in livestock. Regular monitoring programs are established to assess the compliance of animal-derived products with established residue limits. Results from these monitoring efforts inform regulatory decisions and may lead to the adjustment of withdrawal periods or the enforcement of stricter controls on Albendazole use.

In conclusion, the measurement of Albendazole metabolite (ABZ) is a critical aspect of veterinary drug residues and additives management. It ensures food safety, regulatory compliance, and the prevention of drug resistance in the livestock industry. Moreover, ABZ measurement facilitates international trade by aligning with diverse international standards. The scientific understanding of ABZ's role is fundamental for veterinarians, regulatory authorities, and all stakeholders in the animal agriculture sector as they work together to maintain the integrity of the food supply chain and protect animal health.

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