Tilmicosin(TIM) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Tilmicosin(TIM) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Tilmicosin(TIM)

OVA-Tilmicosin(TIM)

Anti-Tilmicosin(TIM) mouse monoclonal antibody

Anti-Tilmicosin(TIM) human monoclonal antibody

Reference

Validation Data

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Biomarker Information

1. Understanding Tiamulin and Its Significance in Veterinary Drug Residues and Additives

Tiamulin, a potent pleuromutilin-class antibiotic, holds paramount importance in the realm of veterinary medicine. Its primary role lies in combating an extensive spectrum of bacterial infections, particularly in swine and poultry. Tiamulin is recognized for its efficacy in treating respiratory ailments, including swine dysentery and enzootic pneumonia in swine, as well as mycoplasma infections in poultry. Its mechanism of action involves the inhibition of bacterial protein synthesis, rendering it highly effective against diverse bacterial strains.

2. The Role of Tiamulin in Veterinary Medicine

Tiamulin's effectiveness in veterinary medicine is rooted in its unique mode of action. It interferes with the bacterial ribosome, specifically binding to the 50S subunit. This binding inhibits the synthesis of proteins necessary for bacterial survival, leading to bacterial cell death. Tiamulin is particularly potent against Gram-positive bacteria and some Gram-negative bacteria, making it a valuable tool in combating a range of respiratory and enteric infections in animals.

3. Food Safety and Tiamulin Residues

In the context of veterinary drug residues and additives, a meticulous evaluation of tiamulin levels is indispensable. This scrutiny is necessitated to uphold food safety standards and ensure adherence to regulatory requirements. The presence of veterinary drug residues, including tiamulin, in consumable animal products such as meat, milk, and eggs poses potential risks to human health.

4. Regulatory Oversight

Regulatory agencies, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), establish maximum residue limits (MRLs) for veterinary drugs, including tiamulin. These limits are set to ensure that the consumption of animal products does not pose a health risk to humans. MRLs are established through rigorous scientific assessment, taking into account factors such as the potential for residues to transfer into food products and the potential impact on human health.

Meeting these MRLs is obligatory for veterinarians, farmers, and the pharmaceutical industry. It is also essential for ensuring compliance with food safety regulations. Failure to comply with these limits can have serious consequences, including legal ramifications. Therefore, accurate and reliable measurement of tiamulin residues is paramount for all stakeholders in the food production chain.

5. Methods for Measuring Tiamulin Residues

Precise and sensitive analytical methods are essential for ascertaining compliance with established safety thresholds. Several techniques are employed to measure tiamulin residues in animal products. These methods include:

1.High-Performance Liquid Chromatography (HPLC): HPLC is a widely used technique for quantifying tiamulin residues. It involves the separation of compounds in a sample based on their interactions with a stationary phase and a mobile phase. Tiamulin can be detected and quantified by comparing its retention time with known standards.

2.Enzyme-Linked Immunosorbent Assay (ELISA): ELISA is an immunological method that relies on the specific binding of antibodies to tiamulin. It is a rapid and sensitive technique for detecting and quantifying tiamulin residues in animal products.

3.Liquid Chromatography-Mass Spectrometry (LC-MS): LC-MS combines the separation capabilities of liquid chromatography with the detection power of mass spectrometry. It is highly accurate and can provide information about the molecular structure of tiamulin residues.

4.Gas Chromatography (GC): GC is another chromatographic technique used to measure tiamulin residues. It involves the vaporization of the sample and separation of its components based on their interactions with a stationary phase.

5.Nuclear Magnetic Resonance (NMR): NMR spectroscopy can provide structural information about tiamulin residues. It is a powerful technique, although less commonly used for routine residue analysis.

6. Importance of Precise Measurement

Accurate quantification of tiamulin residues is essential for several reasons.

a. Food Safety Assurance: Thorough examination of tiamulin residues in animal-derived foodstuffs is an indispensable facet of guaranteeing their safety for human consumption. Elevated residue levels can manifest substantial health hazards, underscoring the need for vigilant monitoring.

b. Regulatory Conformance: Regulatory authorities stipulate maximum residue limits (MRLs) for veterinary drugs, including tiamulin. Striving to meet these limits is obligatory to ensure compliance with food safety regulations. Accurate quantification becomes paramount in order to prevent regulatory non-compliance and associated legal ramifications.

c. Preservation of Animal Health: Beyond human health, the measurement of tiamulin is pivotal in preserving the well-being of animals. Prudent dosing and adherence to withdrawal periods are paramount to forestall the emergence of antibiotic-resistant bacteria and to uphold the health of animals.

d. Advancements in Research and Development: The precision measurement of tiamulin levels underpins the research endeavors of pharmaceutical companies and scientists aimed at enhancing veterinary medications and developing innovative therapeutic approaches. Reliable measurements are pivotal in facilitating research and driving progress in the field of veterinary medicine.

7. Advanced Detection Techniques

In recent years, advanced detection techniques have been developed to enhance the accuracy and sensitivity of tiamulin residue measurements. These include the use of anti-tiamulin antibodies and small molecule competitive antigens in immunoassays, as well as the integration of automation and robotics in sample preparation and analysis.

8. Conclusion

In summary, meticulous tiamulin measurement is instrumental in safeguarding human and animal health, ensuring compliance with regulatory standards, and fostering progressive research and development in the domain of veterinary medicine. Robust detection methods employing cutting-edge anti-tiamulin antibodies and small molecule competitive antigens play a pivotal role in these endeavors. The ongoing refinement of measurement techniques continues to improve our ability to monitor and control tiamulin residues in animal products, further enhancing food safety and the health of both animals and consumers.

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