Doramectin(DOR) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Doramectin(DOR) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Doramectin(DOR)

OVA-Doramectin(DOR)

Anti-Doramectin(DOR) mouse monoclonal antibody

Anti-Doramectin(DOR) human monoclonal antibody

Reference

Validation Data

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Biomarker Information

1.Tylosin (TYL) Overview: Tylosin is a prominent macrolide antibiotic that plays a vital role in veterinary pharmacology. This versatile compound is primarily used in the treatment of bacterial infections in livestock, particularly swine and poultry. With a distinctive 16-membered macrolactone ring in its molecular structure, Tylosin demonstrates efficacy against a wide range of bacterial pathogens, making it a critical tool in the maintenance of animal health and food safety.

2.Measurement Rationale for Tylosin (TYL):

2.1 Ensuring Food Safety: A primary rationale for the measurement of Tylosin is to safeguard the food supply chain. Contaminants such as antibiotics, including Tylosin, can pose risks to consumers if present in animal-derived products. Monitoring and quantifying Tylosin residues in food-producing animals and their by-products is essential to mitigate potential health risks associated with its consumption. This contributes to the overarching goal of upholding stringent food safety standards and ensuring the well-being of consumers.

2.2 Regulatory Compliance: In the context of veterinary pharmaceuticals, regulatory compliance is of paramount importance. Governments and international organizations set maximum residue limits (MRLs) for antibiotics like Tylosin to protect consumers and prevent antibiotic resistance. Accurate measurement of Tylosin residues is imperative to adhere to these established limits. This compliance is non-negotiable for companies engaged in the production and distribution of animal-derived products, as violations can lead to legal consequences and damage to a company's reputation.

2.3 Mitigating Antibiotic Resistance: Tylosin, like other antibiotics, poses a risk of contributing to antibiotic resistance if used improperly or excessively. The overuse or misuse of antibiotics can lead to the development of antibiotic-resistant bacterial strains, which is a significant public health concern. Monitoring Tylosin levels in animals helps to encourage responsible use and minimize the risk of antibiotic resistance. It promotes the judicious use of antibiotics in veterinary medicine and livestock production.

2.4 Quality Control in Animal Feed: In some scenarios, Tylosin is employed as an additive in animal feed. This practice is particularly common in poultry and swine production to promote growth and prevent disease. To ensure the safety and effectiveness of such feed additives, regular measurement of Tylosin becomes crucial. This ensures precise dosing and adherence to recommended concentrations, maintaining the desired effects on animal health and growth while minimizing unintended consequences.

2.5 Research and Development Enhancement: Pharmaceutical and biopharmaceutical entities actively involved in the development of veterinary drugs rely on the accurate measurement of Tylosin levels during formulation and testing phases. This practice is essential to ensure product efficacy and safety. It also aligns with a commitment to scientific rigor and contributes to the development of new and improved antibiotics and veterinary medicines.

2.6 Market Competitiveness: Companies involved in the production of animal-derived products, such as meat, milk, and eggs, strive to guarantee the production of high-quality, Tylosin-free products. Adhering to stringent regulatory standards and ensuring the absence of antibiotic residues enhances a company's reputation and competitive advantage in the marketplace. This fosters consumer confidence in their offerings and cultivates a robust presence in the sector, which is essential in today's highly competitive food industry.

3.Analytical Methods for Measuring Tylosin (TYL):

3.1 High-Performance Liquid Chromatography (HPLC): HPLC is a widely used method for quantifying Tylosin in various matrices, including animal tissues, feed, and milk. It offers high sensitivity and precision, making it a preferred choice for regulatory testing and research applications. HPLC separates and quantifies Tylosin based on its chemical properties and can detect trace amounts of the antibiotic.

3.2 Liquid Chromatography-Mass Spectrometry (LC-MS): LC-MS is a powerful technique that combines the separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry. LC-MS is highly sensitive and can provide structural information about the compounds detected. It is often used in research and quality control settings for Tylosin analysis.

3.3 Enzyme-Linked Immunosorbent Assay (ELISA): ELISA is an immunoassay technique that uses antibodies to detect and quantify specific molecules, such as Tylosin. It is a rapid and cost-effective method that is commonly used for screening purposes in food safety and quality control.

3.4 Microbiological Assays: Microbiological assays rely on the growth inhibition of specific bacterial strains in the presence of Tylosin. While not as precise as chromatographic methods, these assays are relatively simple and can be used for screening purposes.

4.Conclusion: Tylosin, as a macrolide antibiotic, holds a crucial position in veterinary pharmacology. Its accurate measurement is essential for various reasons, including ensuring food safety, regulatory compliance, mitigating antibiotic resistance, maintaining quality control in animal feed, supporting research and development efforts, and enhancing market competitiveness. A range of analytical methods is available for measuring Tylosin, allowing for its effective monitoring in different applications. As the importance of responsible antibiotic use and food safety continues to grow, the accurate measurement of Tylosin remains a critical component of modern animal agriculture and veterinary medicine.

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