Amantadine (AM) antibody and antigen (hapten, BSA/OVA conjugated)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-SMT-169-Ag01	BSA-Amantadine (AM)	756
GMP-SMT-169-Ag02	OVA-Amantadine (AM)	756
GMP-SMT-169-Ab01	Anti-human Amantadine (AM) mouse monoclonal antibody (mAb)	1953
GMP-SMT-169-Ab02	Anti-human Amantadine (AM) human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-SMT-169-Ag01
Product Name	BSA-Amantadine (AM)
Target/Biomarker	Amantadine (AM)
Expression platform	Synthetic
Isotypes	NA
Bioactivity validation	Amantadine (AM) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AM level test of Infectious disease/Neurodegenerative diseases (Influenza A, Parkinson's disease) and related syndrome evaluation.
Tag	NA
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Amantadine (AM) / OVA-Amantadine (AM) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-SMT-169-Ag02
Product Name	OVA-Amantadine (AM)
Target/Biomarker	Amantadine (AM)
Expression platform	Synthetic
Isotypes	NA
Bioactivity validation	Amantadine (AM) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AM level test of Infectious disease/Neurodegenerative diseases (Influenza A, Parkinson's disease) and related syndrome evaluation.
Tag	NA
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Amantadine (AM) / OVA-Amantadine (AM) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-SMT-169-Ab01
Product Name	Anti-human Amantadine (AM) mouse monoclonal antibody (mAb)
Target/Biomarker	Amantadine (AM)
Expression platform	Hybridoma
Isotypes	Mouse IgG
Bioactivity validation	Amantadine (AM) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AM level test of Infectious disease/Neurodegenerative diseases (Influenza A, Parkinson's disease) and related syndrome evaluation.
Tag	mFc
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Amantadine (AM) / OVA-Amantadine (AM) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA),Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-SMT-169-Ab02
Product Name	Anti-human Amantadine (AM) human monoclonal antibody (mAb)
Target/Biomarker	Amantadine (AM)
Expression platform	Hybridoma
Isotypes	Mouse IgG
Bioactivity validation	Amantadine (AM) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AM level test of Infectious disease/Neurodegenerative diseases (Influenza A, Parkinson's disease) and related syndrome evaluation.
Tag	mFc
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Amantadine (AM) / OVA-Amantadine (AM) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA),Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

1. Detailed Overview of Amantadine and Its Diagnostic Significance Amantadine hydrochloride, a synthetic adamantane derivative, exhibits a broad spectrum of pharmacological activities, prominently including antiviral and antiparkinsonian properties. As an antiviral agent, it primarily interferes with the replication cycle of the influenza A virus, notably by blocking the M2 proton channel, thereby preventing viral uncoating and subsequent replication in host cells. In the realm of neurology, Amantadine enhances dopaminergic function, which is beneficial in managing Parkinson's disease symptoms and drug-induced extrapyramidal reactions by releasing dopamine from nerve endings and inhibiting its reuptake. The molecular specificity and pharmacodynamic profile of Amantadine make it an invaluable target for in vitro diagnostic testing, particularly in therapeutic drug monitoring (TDM). The development of high-affinity antibodies against Amantadine, alongside the creation of small molecule competitive antigens, forms the cornerstone of immunoassays designed to accurately quantify Amantadine concentrations in biological samples. These assays are vital for evaluating drug efficacy, adjusting dosages to avoid toxic levels, and ensuring patient adherence to treatment plans. Furthermore, the ability to monitor Amantadine levels is instrumental in research and clinical practice for understanding drug metabolism variations across populations, which can influence treatment outcomes. 2. Importance of Measuring Amantadine in Clinical Practice The quantification of Amantadine concentrations in patient samples is paramount for several interconnected reasons in clinical pharmacology and personalized medicine: Therapeutic Drug Monitoring (TDM) TDM is an essential clinical practice that ensures drug levels remain within a therapeutic range that maximizes efficacy while minimizing adverse effects. Given Amantadine's narrow therapeutic index, precise measurement is crucial to avoid underdosing, which may lead to therapeutic failure, or overdosing, which can result in toxicity, including neurological and cardiac side effects. Patient Compliance and Pharmacokinetic Variability Regular monitoring of Amantadine levels can serve as an indicator of patient compliance, a significant factor in the successful management of chronic conditions such as Parkinson's disease. Moreover, individual differences in drug metabolism — influenced by genetic factors, age, renal function, and interactions with other medications — necessitate personalized dose adjustments. Quantitative analysis of Amantadine facilitates these adjustments, ensuring optimal therapeutic outcomes. Resistance Management and Personalized Medicine In the context of antiviral therapy, monitoring drug levels is crucial for preventing the emergence of drug-resistant strains of the influenza A virus, which can occur when sub-therapeutic drug concentrations allow for viral mutation and selection. Additionally, TDM supports the principles of personalized medicine by enabling healthcare providers to tailor treatment strategies based on the unique metabolic and pharmacokinetic profiles of individual patients, thereby enhancing the efficacy and safety of Amantadine therapy. In summary, the precise measurement of Amantadine through in vitro diagnostic methods plays a pivotal role in clinical decision-making. It supports therapeutic drug monitoring, ensures patient adherence, accommodates pharmacokinetic variability, aids in resistance management, and underpins personalized medicine approaches. This comprehensive approach to drug monitoring underscores the importance of advanced diagnostic tools and methodologies in optimizing patient care and therapeutic strategies.

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