Microcystin LR(MC-LR) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-SMT-156-1	1. BSA-Microcystin LR(MC-LR) 2. Anti-Microcystin LR(MC-LR) mouse monoclonal antibody	$2709.00
GMP-SMT-156-2	1. OVA-Microcystin LR(MC-LR) 2. Anti-Microcystin LR(MC-LR) mouse monoclonal antibody	$2709.00
GMP-SMT-156-3	1. BSA-Microcystin LR(MC-LR) 2. Anti-Microcystin LR(MC-LR) human monoclonal antibody	$2709.00
GMP-SMT-156-4	1. OVA-Microcystin LR(MC-LR) 2. Anti-Microcystin LR(MC-LR) human monoclonal antibody	$2709.00
GMP-SMT-156-Ag-1	BSA-Microcystin LR(MC-LR)	$756.00
GMP-SMT-156-Ag-2	OVA-Microcystin LR(MC-LR)	$756.00
GMP-SMT-156-Ab-1	Anti-Microcystin LR(MC-LR) mouse monoclonal antibody	$1953.00
GMP-SMT-156-Ab-2	Anti-Microcystin LR(MC-LR) human monoclonal antibody	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

BSA-Microcystin LR(MC-LR)

Cat No.	GMP-SMT-156-Ag-1
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Microcystin LR(MC-LR) with anti-Hapten antibody. The hapten hapten-carrier conjugates BSA-Microcystin LR(MC-LR) had been validated with our anti-Hapten antibody Anti-Microcystin LR(MC-LR) mouse monoclonal antibody via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

OVA-Microcystin LR(MC-LR)

Cat No.	GMP-SMT-156-Ag-2
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description	Competitive immunoassay-validated hapten-carrier conjugates OVA-Microcystin LR(MC-LR) with anti-Hapten antibody. The hapten hapten-carrier conjugates OVA-Microcystin LR(MC-LR) had been validated with our anti-Hapten antibody Anti-Microcystin LR(MC-LR) mouse monoclonal antibody via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-Microcystin LR(MC-LR) mouse monoclonal antibody

Cat No.	GMP-SMT-156-Ab-1
Host of Antibody	Mouse IgG
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb)	0.1-0.2
Products description	The anti-Hapten antibody against hapten Microcystin LR(MC-LR) had been validated with our hapten hapten-carrier conjugates BSA-Microcystin LR(MC-LR) via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-Microcystin LR(MC-LR) human monoclonal antibody

Cat No.	GMP-SMT-156-Ab-2
Host of Antibody	Human IgG1
Bioactivity validation	Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody; Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb)	0.1-0.2
Products description	The anti-Hapten antibody against hapten Microcystin LR(MC-LR) had been validated with our hapten hapten-carrier conjugates BSA-Microcystin LR(MC-LR) via competitive ELISA test.
Application	ELISA tests and other immunoassays; Lateral flow immunoassay (LFIA); LTIA Immunonephelometry Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Figure: GeneMedi's GMP-SMT-156-Ab-1 is validated to detect the GMP-SMT-156-Ag-1 in ELISA. EC50= 1.913 ppb.

Click to get more Data / Case study about the product.

Biomarker Information

1. Microcystin LR (MC-LR) in Mycotoxins:

Microcystin LR (MC-LR) stands as a prominent member of the mycotoxin family, playing a significant and multifaceted role in both environmental and biopharmaceutical research realms. Mycotoxins represent a class of toxic secondary metabolites produced by select molds and fungi, with MC-LR occupying a pivotal position within this cohort.

Environmental Context (#1): MC-LR frequently surfaces in freshwater ecosystems, particularly in the context of cyanobacterial blooms, also referred to as harmful algal blooms (HABs). These blooms, often associated with eutrophication and environmental perturbations, have the propensity to generate substantial quantities of MC-LR. As a result, MC-LR becomes a focal point of ecological concern, primarily due to its potential toxicity to aquatic organisms and its profound influence on overall water quality dynamics.

In the realm of environmental research, MC-LR's significance is manifest in several dimensions:

Toxicological Implications: MC-LR is recognized for its hepatotoxicity and has been implicated in numerous cases of animal and human poisonings. Consequently, meticulous investigations delve into elucidating the toxicological mechanisms underpinning MC-LR's adverse effects on aquatic life forms.

Ecological Impact: Researchers scrutinize MC-LR's ecological impact, encompassing its role in food web dynamics, trophic transfer, and potential disruptions to aquatic ecosystems. Understanding MC-LR's repercussions on biodiversity and ecosystem functioning is critical for informed environmental management.

Detection and Removal: Strategies for the detection and removal of MC-LR from aquatic systems are a key facet of research efforts. The development of sensitive and reliable analytical methods for MC-LR quantification is pivotal, as it aids in monitoring water quality and identifying potential health hazards.

Biopharmaceutical Significance (#2): In the biopharmaceutical domain, MC-LR assumes a dual role as both a research tool and a reference material. Its pertinence is particularly evident in the development of antibodies and immunoassays targeting MC-LR, and it plays a critical role as a competitive antigen.

Antibody Development: MC-LR serves as a foundational element in the development of antibodies tailored for mycotoxin detection. Researchers leverage its unique chemical structure and immunogenicity to generate specific antibodies that recognize and bind to MC-LR with high affinity and selectivity.

Immunoassay Validation: MC-LR plays a crucial role in the validation and standardization of immunoassays designed for mycotoxin detection. This process involves the use of MC-LR as a reference material to assess the accuracy, precision, and sensitivity of immunoassay methods, ensuring their reliability in real-world applications.

Competitive Antigen: MC-LR's utility as a competitive antigen is instrumental in the development of immunoassays. By competing with the target MC-LR molecules in a sample, it facilitates the quantification of MC-LR concentrations with precision, allowing for the development of highly sensitive detection methods.

2. The Significance of Measuring Microcystin LR (MC-LR):

The measurement of Microcystin LR (MC-LR) transcends mere scientific curiosity and encompasses a tapestry of compelling motivations, each contributing to its profound significance in environmental preservation, public health protection, rigorous scientific inquiry, regulatory adherence, and innovative biopharmaceutical research.

a. Environmental Monitoring (#1): Vigilant and systematic monitoring of MC-LR levels within freshwater ecosystems is imperative for a multitude of reasons, serving as the cornerstone for assessing contamination extent and associated ecological risks, notably emanating from harmful algal blooms (HABs).

Contamination Assessment: MC-LR measurement provides a quantifiable metric for assessing the extent of contamination within aquatic systems. This quantitative data enables researchers and environmental authorities to gauge the severity of MC-LR presence and its potential impact on aquatic biota and ecosystems.

Ecological Risk Evaluation: The presence of MC-LR in aquatic environments raises concerns regarding its toxicity to aquatic organisms. Rigorous measurement protocols are employed to evaluate the ecological risks posed by MC-LR, thereby guiding environmental management strategies and conservation efforts.

Water Quality Management: MC-LR measurement is indispensable for making informed decisions regarding water quality management. Accurate data allows for the timely implementation of mitigation measures to safeguard water quality, protect aquatic ecosystems, and ensure the sustainability of water resources.

b. Public Health Concerns (#2): MC-LR poses tangible health risks to both humans and animals when present in drinking water sources. Rigorous and systematic MC-LR measurement in water supplies is pivotal for various reasons.

Safety Regulation Compliance: MC-LR measurement ensures compliance with safety regulations and guidelines established by regulatory authorities. By quantifying MC-LR levels in drinking water, water treatment facilities and authorities can verify adherence to safety standards and protect public health.

Health Hazard Mitigation: Timely detection of MC-LR contamination is vital for public health protection. Rapid measurement protocols enable the prompt implementation of mitigation measures, such as water treatment and advisories, to minimize potential health hazards associated with MC-LR exposure.

c. Scientific Research (#1 and #2): MC-LR assumes a central role in scientific research, spanning both environmental science and biopharmaceutical inquiry. Its precise measurement is essential for advancing our understanding of MC-LR's behavior, impacts, and applications.

Toxicological Studies: MC-LR is a subject of extensive toxicological research. Precise measurement of MC-LR concentrations is instrumental in elucidating its mechanisms of toxicity, cellular effects, and potential long-term health consequences.

Environmental Fate and Behavior: Understanding MC-LR's fate and behavior in aquatic environments is critical for predicting its ecological impact. Measurement data aids in modeling MC-LR's distribution, transport, and persistence, informing environmental management strategies.

Biopharmaceutical Research: MC-LR's significance in biopharmaceutical research is underscored by its role in antibody development and immunoassay validation. Accurate MC-LR measurement is pivotal for ensuring the reliability and efficacy of immunoassay methods used in mycotoxin detection.

d. Regulatory Adherence (#2): Regulatory bodies in various regions have established permissible thresholds for MC-LR concentrations within drinking water sources, underlining the importance of systematic measurement and monitoring.

Regulatory Compliance: Rigorous MC-LR measurement protocols are employed to ensure compliance with regulatory limits. Water utilities and authorities routinely measure MC-LR levels to demonstrate adherence to safety regulations, thereby safeguarding public health and regulatory compliance.

Environmental Protection: MC-LR measurement

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