Feline proBNP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-proBNP-Ag01	Recombinant Feline proBNP protein	3090
GMP-FEL-proBNP-Ab01	Anti-Feline proBNP mouse monoclonal antibody (mAb)	1953
GMP-FEL-proBNP-Ab02	Anti-Feline proBNP mouse monoclonal antibody (mAb)	1953
GMP-FEL-proBNP-Ab03	Anti-Feline proBNP human monoclonal antibody (mAb)	1953
GMP-FEL-proBNP-Ab04	Anti-Feline proBNP human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-FEL-proBNP-Ag01
Product Name	Recombinant Feline proBNP protein
Target/Biomarker	Feline pro B-type natriuretic peptide (proBNP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline pro B-type natriuretic peptide antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in proBNP level test of animal Cat/Feline with intrinsic cardiac dysfunction.
Tag	His
Products description	Recombinant Feline proBNP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-proBNP-Ab01, GMP-FEL-proBNP-Ab02
Product Name	Anti-Feline proBNP mouse monoclonal antibody (mAb)
Target/Biomarker	Feline pro B-type natriuretic peptide (proBNP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline pro B-type natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies in proBNP level test of animal Cat/Feline with intrinsic cardiac dysfunction.
Tag	mFc
Products description	Anti-Feline proBNP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-proBNP-Ab03, GMP-FEL-proBNP-Ab04
Product Name	Anti-Feline proBNP human monoclonal antibody (mAb)
Target/Biomarker	Feline pro B-type natriuretic peptide (proBNP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline pro B-type natriuretic peptide antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies in proBNP level test of animal Cat/Feline with intrinsic cardiac dysfunction.
Tag	hFc
Products description	Anti-Feline proBNP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-proBNP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Feline proBNP, or pro-brain natriuretic peptide, is an intriguing biomarker exclusive to cats. It is a prohormone consisting of 108 amino acids, initially synthesized and released by the cardiac ventricles in response to increased stretch and stress. This molecular precursor serves as the foundation for the active hormone B-type natriuretic peptide (BNP), which plays a central role in regulating cardiovascular homeostasis. When the heart faces pressure or volume overload, as seen in conditions like hypertrophic cardiomyopathy (HCM) or congestive heart failure (CHF), the production of proBNP escalates as an adaptive response. ProBNP acts as a physiological modulator, promoting vasodilation, sodium excretion, and diuresis to alleviate the cardiac workload and restore equilibrium within the cardiovascular system. As such, proBNP serves as a sentinel, finely tuned to cardiac hemodynamics and ready to signal any perturbations. Understanding the intricacies of proBNP synthesis, processing, and release is critical for comprehending feline cardiac health and diagnosing heart-related disorders with precision.

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