Feline p-tau212 and 214 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-p-tau212-214-Ag01	Recombinant Feline p-tau212 and 214 protein	3090
GMP-FEL-p-tau212-214-Ab01	Anti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb)	1953
GMP-FEL-p-tau212-214-Ab02	Anti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb)	1953
GMP-FEL-p-tau212-214-Ab03	Anti-Feline p-tau212 and 214 human monoclonal antibody (mAb)	1953
GMP-FEL-p-tau212-214-Ab04	Anti-Feline p-tau212 and 214 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-p-tau212-214-Ag01
Product Name	Recombinant Feline p-tau212 and 214 protein
Target/Biomarker	Feline Phospho-Tau212 And 214 (p-tau212 and 214)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Phospho-Tau212 And 214 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau212 and 214 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Feline p-tau212 and 214 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-p-tau212-214-Ab01, GMP-FEL-p-tau212-214-Ab02
Product Name	Anti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Phospho-Tau212 And 214 (p-tau212 and 214)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Phospho-Tau212 And 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau212 and 214 antibodies in p-tau212 and 214 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau212 and 214 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-p-tau212-214-Ab03, GMP-FEL-p-tau212-214-Ab04
Product Name	Anti-Feline p-tau212 and 214 human monoclonal antibody (mAb)
Target/Biomarker	Feline Phospho-Tau212 And 214 (p-tau212 and 214)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Phospho-Tau212 And 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau212 and 214 antibodies in p-tau212 and 214 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Feline p-tau212 and 214 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau212 and 214 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Feline p-tau212 and p-tau214, constituents of the tau protein family, represent a captivating facet of feline neurobiology. These phosphorylated tau variants are specifically tailored to the intricate neural landscape of cats, playing a pivotal role in maintaining neuronal stability and axonal integrity. However, the story of p-tau212 and p-tau214 takes a dramatic turn in the context of neurodegenerative diseases in felines. At its core, tau is a microtubule-associated protein that binds to and stabilizes microtubules within neurons. This function is vital for maintaining the structural integrity of neurons and facilitating essential processes such as axonal transport. Tau phosphorylation, a naturally occurring process, regulates its interaction with microtubules. However, when tau becomes hyperphosphorylated, as observed in neurodegenerative conditions, it undergoes a transformation that renders it dysfunctional. Feline p-tau212 and p-tau214 are two specific sites of phosphorylation on the tau protein that hold a particular clinical significance in cats. These phosphorylated forms are notorious for their propensity to form aggregates and insoluble structures, known as neurofibrillary tangles. These tangles wreak havoc within feline neurons, disrupting axonal transport, and impairing neuronal function. The consequence is the gradual but relentless cognitive decline observed in aging cats and those affected by conditions like feline cognitive dysfunction syndrome (FCDS).

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