Feline p-tau202 and 205 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-p-tau202-205-Ag01	Recombinant Feline p-tau202 and 205 protein	3090
GMP-FEL-p-tau202-205-Ab01	Anti-Feline p-tau202 and 205 mouse monoclonal antibody (mAb)	1953
GMP-FEL-p-tau202-205-Ab02	Anti-Feline p-tau202 and 205 mouse monoclonal antibody (mAb)	1953
GMP-FEL-p-tau202-205-Ab03	Anti-Feline p-tau202 and 205 human monoclonal antibody (mAb)	1953
GMP-FEL-p-tau202-205-Ab04	Anti-Feline p-tau202 and 205 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-p-tau202-205-Ag01
Product Name	Recombinant Feline p-tau202 and 205 protein
Target/Biomarker	Feline Phospho-tau202 and 205 (p-tau202 and 205)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Phospho-tau202 and 205 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau202 and 205 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Feline p-tau202 and 205 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-p-tau202-205-Ab01, GMP-FEL-p-tau202-205-Ab02
Product Name	Anti-Feline p-tau202 and 205 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Phospho-tau202 and 205 (p-tau202 and 205)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Phospho-tau202 and 205 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau202 and 205 antibodies in p-tau202 and 205 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Feline p-tau202 and 205 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau202 and 205 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-p-tau202-205-Ab03, GMP-FEL-p-tau202-205-Ab04
Product Name	Anti-Feline p-tau202 and 205 human monoclonal antibody (mAb)
Target/Biomarker	Feline Phospho-tau202 and 205 (p-tau202 and 205)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Phospho-tau202 and 205 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau202 and 205 antibodies in p-tau202 and 205 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Feline p-tau202 and 205 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau202 and 205 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Associated products

Target/Biomarker information

Feline p-tau202 and p-tau205, the phosphorylated Tau Protein 202 and 205 variants specific to cats, stand as key entities in the intricate tapestry of feline neurobiology. At their core, they are Tau proteins that have undergone precise biochemical modifications – phosphorylation – at residues 202 and 205, respectively. Tau proteins, in their unmodified form, are essential for maintaining microtubule stability within neuronal cells, ensuring proper axonal structure and intracellular transport. However, the story takes a dramatic turn in the context of neurodegenerative diseases. Phosphorylation events can trigger the misfolding and aggregation of Tau proteins, and feline p-tau202 and p-tau205 are particularly susceptible to this transformation. They tend to aggregate and form neurofibrillary tangles within the neural tissues of afflicted cats. These neurofibrillary tangles, similar to those observed in human neurodegenerative diseases like Alzheimer's, serve as a pathological hallmark of various feline neurodegenerative conditions. The accumulation of p-tau202 and p-tau205 in these tangles contributes to progressive neuronal dysfunction, synaptic disruption, and cognitive impairment, which are observed in conditions such as feline cognitive dysfunction syndrome (FCDS).

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