Feline p-tau181 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-p-tau181-Ag01	Recombinant Feline p-tau181 protein	3090
GMP-FEL-p-tau181-Ab01	Anti-Feline p-tau181 mouse monoclonal antibody (mAb)	1953
GMP-FEL-p-tau181-Ab02	Anti-Feline p-tau181 mouse monoclonal antibody (mAb)	1953
GMP-FEL-p-tau181-Ab03	Anti-Feline p-tau181 human monoclonal antibody (mAb)	1953
GMP-FEL-p-tau181-Ab04	Anti-Feline p-tau181 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-p-tau181-Ag01
Product Name	Recombinant Feline p-tau181 protein
Target/Biomarker	Feline Phospho-tau181 (p-tau181)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Phospho-tau181 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau181 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Feline p-tau181 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-p-tau181-Ab01, GMP-FEL-p-tau181-Ab02
Product Name	Anti-Feline p-tau181 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Phospho-tau181 (p-tau181)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Phospho-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau181 antibodies in p-tau181 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Feline p-tau181 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau181 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-p-tau181-Ab03, GMP-FEL-p-tau181-Ab04
Product Name	Anti-Feline p-tau181 human monoclonal antibody (mAb)
Target/Biomarker	Feline Phospho-tau181 (p-tau181)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Phospho-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau181 antibodies in p-tau181 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Feline p-tau181 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau181 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Associated products

Target/Biomarker information

Feline p-tau181, the phosphorylated Tau Protein 181 variant unique to cats, takes center stage in the intricate tapestry of feline neurobiology. At its core, it is a Tau protein that has undergone precise biochemical modification – phosphorylation – specifically at residue 181. Tau proteins, under normal circumstances, are the guardians of microtubule stability, ensuring the structural integrity of neuronal axons and enabling proper intracellular transport. However, when neurodegenerative processes unfold, the narrative shifts dramatically. Phosphorylation events can trigger the misfolding and aggregation of Tau proteins, and feline p-tau181 is no exception. It tends to aggregate and form neurofibrillary tangles (NFTs) within the neural tissues of afflicted cats. These NFTs, akin to those observed in human neurodegenerative diseases such as Alzheimer's, are a pathological signature of various feline neurodegenerative conditions. The accumulation of p-tau181 in NFTs contributes to progressive neuronal dysfunction, cognitive decline, and motor disturbances, as evident in conditions like feline cognitive dysfunction syndrome (FCDS) and specific encephalopathies.

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