Feline cTnI antibody and antigen (recombinant protein)
Diagnostic anti-Feline cTnI antibodies pairs and antigen for animal health (animal Cat/Feline Myocardial injury, heart disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
Catalog No. | Description | US $ Price (per mg) |
---|---|---|
GMP-FEL-cTnI-Ag01 | Recombinant Feline cTnI protein | 3090 |
GMP-FEL-cTnI-Ab01 | Anti-Feline cTnI mouse monoclonal antibody (mAb) | 1953 |
GMP-FEL-cTnI-Ab02 | Anti-Feline cTnI mouse monoclonal antibody (mAb) | 1953 |
GMP-FEL-cTnI-Ab03 | Anti-Feline cTnI human monoclonal antibody (mAb) | 1953 |
GMP-FEL-cTnI-Ab04 | Anti-Feline cTnI human monoclonal antibody (mAb) | 1953 |
Size: 1mg | 10mg | 100mg
Product Description
Cat No. of Products | GMP-FEL-cTnI-Ag01 |
Product Name | Recombinant Feline cTnI protein |
Target/Biomarker | Feline Cardiac troponin I (cTnI) |
Expression platform | E.coli |
Isotypes | Recombinant Antigen |
Bioactivity validation | Anti-Feline Cardiac troponin I antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in cTnI level test of animal Cat/Feline with Myocardial injury, heart disease. |
Tag | His |
Products description | Recombinant Feline cTnI protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. of Products | GMP-FEL-cTnI-Ab01, GMP-FEL-cTnI-Ab02 |
Product Name | Anti-Feline cTnI mouse monoclonal antibody (mAb) |
Target/Biomarker | Feline Cardiac troponin I (cTnI) |
Expression platform | CHO |
Isotypes | Mouse IgG |
Bioactivity validation | Recombinant Feline Cardiac troponin I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies in cTnI level test of animal Cat/Feline with Myocardial injury, heart disease. |
Tag | mFc |
Products description | Anti-Feline cTnI mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. of Products | GMP-FEL-cTnI-Ab03, GMP-FEL-cTnI-Ab04 |
Product Name | Anti-Feline cTnI human monoclonal antibody (mAb) |
Target/Biomarker | Feline Cardiac troponin I (cTnI) |
Expression platform | CHO |
Isotypes | Human IgG1 |
Bioactivity validation | Recombinant Feline Cardiac troponin I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies in cTnI level test of animal Cat/Feline with Myocardial injury, heart disease. |
Tag | hFc |
Products description | Anti-Feline cTnI human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-cTnI antibodies. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
GeneMedi's feline cTnI antibodies exhibit superior performance in sandwich immunoassays.
GeneMedi’s GMP-FEL-cTnI-Ab01, GMP-FEL-cTnI-Ab02, and GMP-FEL-cTnI-Ab05 demonstrate superior performance in sandwich ELISA assays. We tested four antibody pairs, and the GMP-FEL-cTnI-Ab01 and GMP-FEL-cTnI-Ab02 pair showed the lowest EC50. Based on these results, we recommend this antibody pair for optimal performance in cTnI detection.
Figure 1. The performance of GeneMedi’s feline cTnI antibodies in sandwich ELISA assays.
A-B. Results of four different antibody pairs in sandwich ELISA assays.
C. Antibody pairs and their EC50 values.
Click to get more Data / Case study about the product.
Target/Biomarker information
Cardiac Troponin I (cTnI) is a protein of exceptional significance in the context of feline physiology. This cardiac-specific biomarker is predominantly found in the bloodstream of cats (felines) and serves as a crucial indicator of cardiac health. To truly appreciate the role of cTnI, it is essential to delve into its structural composition, functional significance, and its position within the realm of feline cardiology. Structurally, cTnI is one of the three subunits of the troponin complex, the other two being cardiac Troponin T (cTnT) and cardiac Troponin C (cTnC). The troponin complex resides within the sarcomeres of cardiac muscle fibers, where it meticulously regulates muscle contraction. This precision is vital for the rhythmic and efficient pumping of blood by the heart. What distinguishes cTnI is its exclusive cardiac specificity. While other troponin isoforms exist in skeletal muscle, cTnI is uniquely expressed in the heart. This specificity makes cTnI an exceptionally valuable biomarker for assessing cardiac muscle injury or damage. When cardiac cells are compromised due to factors such as myocardial infarction, cardiac diseases, or cardiac trauma, cTnI is released into the bloodstream. Therefore, elevated levels of cTnI in a cat's blood can serve as a critical diagnostic indicator of cardiac health. Detecting cTnI levels in feline serum is typically achieved through immunoassays, such as enzyme-linked immunosorbent assays (ELISA). These assays provide a quantitative measure of cTnI concentration, enabling veterinarians to assess the extent of cardiac injury or disease. The sensitivity of these assays is such that even minor myocardial damage can lead to detectable elevations in cTnI levels, allowing for early diagnosis and intervention.
About GDU
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