Feline YKL-40 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-YKL-40-Ag01	Recombinant Feline YKL-40 protein	3090
GMP-FEL-YKL-40-Ab01	Anti-Feline YKL-40 mouse monoclonal antibody (mAb)	1953
GMP-FEL-YKL-40-Ab02	Anti-Feline YKL-40 mouse monoclonal antibody (mAb)	1953
GMP-FEL-YKL-40-Ab03	Anti-Feline YKL-40 human monoclonal antibody (mAb)	1953
GMP-FEL-YKL-40-Ab04	Anti-Feline YKL-40 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-YKL-40-Ag01
Product Name	Recombinant Feline YKL-40 protein
Target/Biomarker	Feline Chitinase-3-Like Protein 1 (YKL-40)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Chitinase-3-Like Protein 1 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in YKL-40 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Feline YKL-40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-YKL-40-Ab01, GMP-FEL-YKL-40-Ab02
Product Name	Anti-Feline YKL-40 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Chitinase-3-Like Protein 1 (YKL-40)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Chitinase-3-Like Protein 1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies in YKL-40 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Feline YKL-40 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-YKL-40-Ab03, GMP-FEL-YKL-40-Ab04
Product Name	Anti-Feline YKL-40 human monoclonal antibody (mAb)
Target/Biomarker	Feline Chitinase-3-Like Protein 1 (YKL-40)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Chitinase-3-Like Protein 1 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies in YKL-40 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Feline YKL-40 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-YKL-40 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Feline YKL-40, a glycoprotein of approximately 40 kDa, emerges as a fascinating molecular actor in the intricate theater of the feline immune system and tissue physiology. While it shares structural features with chitinases, it notably lacks chitinase activity, setting it apart from its enzymatic counterparts. Its presence is pervasive in various feline tissues, with prominent expression in the liver, kidneys, lungs, and immune cells. Structurally, Feline YKL-40 is characterized by its unique chitin-binding domain, which can interact with extracellular matrix components, suggesting a role in tissue remodeling and repair. This glycoprotein's glycosylation also contributes to its stability and modulates its functions, particularly in the context of inflammation. The expression of Feline YKL-40 is tightly regulated and can be induced by various pro-inflammatory stimuli. Immune cells, such as macrophages and neutrophils, are prominent sources of YKL-40 production in response to infections and inflammatory signals. This induction reflects its role as a pro-inflammatory mediator and a marker of immune system activation. Beyond its involvement in immune responses, Feline YKL-40 has been associated with tissue remodeling processes. In conditions characterized by tissue injury and repair, such as wound healing and fibrosis, YKL-40's interactions with fibroblasts and epithelial cells become particularly relevant. It appears to modulate cellular activities related to extracellular matrix turnover and tissue restructuring.

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