Feline VDBP antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-VDBP-Ag01	Recombinant Feline VDBP protein	3090
GMP-FEL-VDBP-Ab01	Anti-Feline VDBP mouse monoclonal antibody (mAb)	1953
GMP-FEL-VDBP-Ab02	Anti-Feline VDBP mouse monoclonal antibody (mAb)	1953
GMP-FEL-VDBP-Ab03	Anti-Feline VDBP human monoclonal antibody (mAb)	1953
GMP-FEL-VDBP-Ab04	Anti-Feline VDBP human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-FEL-VDBP-Ag01
Product Name	Recombinant Feline VDBP protein
Target/Biomarker	Feline vitamin D binding protein (sFlt-1)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline vitamin D binding protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in sFlt-1 level test of animal Cat/Feline with liver failure, type I diabetes, cystic fibrosis.
Tag	His
Products description	Recombinant Feline VDBP protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-VDBP-Ab01, GMP-FEL-VDBP-Ab02
Product Name	Anti-Feline VDBP mouse monoclonal antibody (mAb)
Target/Biomarker	Feline vitamin D binding protein (sFlt-1)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline vitamin D binding protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sFlt-1 antibodies in sFlt-1 level test of animal Cat/Feline with liver failure, type I diabetes, cystic fibrosis.
Tag	mFc
Products description	Anti-Feline VDBP mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sFlt-1 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-VDBP-Ab03, GMP-FEL-VDBP-Ab04
Product Name	Anti-Feline VDBP human monoclonal antibody (mAb)
Target/Biomarker	Feline vitamin D binding protein (sFlt-1)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline vitamin D binding protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sFlt-1 antibodies in sFlt-1 level test of animal Cat/Feline with liver failure, type I diabetes, cystic fibrosis.
Tag	hFc
Products description	Anti-Feline VDBP human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-sFlt-1 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Vitamin D Binding Protein (VDBP) in cats, or felines, occupies a pivotal position in the intricate tapestry of feline physiology, orchestrating the complex symphony of vitamin D metabolism and transportation. This multifunctional protein, predominantly synthesized in the liver, plays an indispensable role in ensuring the efficient utilization of vitamin D, a vital fat-soluble nutrient for feline health. VDBP's primary role is that of a guardian of vitamin D, a crucial component of feline well-being. Vitamin D is a master regulator, orchestrating calcium homeostasis, bone health, and immune system function. However, this fat-soluble vitamin comes with unique transportation challenges. Vitamin D doesn't readily dissolve in water, making it challenging to navigate the aqueous environment of the bloodstream. Herein lies the remarkable function of VDBP. VDBP, acting as a faithful chaperone, binds to vitamin D and its metabolites, including calcidiol and calcitriol. This binding not only enhances the solubility of these compounds but also ensures their safe passage through the bloodstream to reach their intended destinations. These destinations include the intestines, where vitamin D is essential for calcium absorption, as well as the bones, where it supports bone mineralization, and immune cells, where it modulates the immune response. The importance of VDBP's transport function cannot be overstated. In the intestines, it facilitates calcium absorption, a cornerstone of skeletal health in cats. Calcium is a fundamental mineral for bone strength, muscle function, and overall body integrity, and its regulation is intricately tied to vitamin D. VDBP ensures that vitamin D is available in sufficient quantities to uphold calcium homeostasis, safeguarding bone integrity and overall feline well-being. Moreover, vitamin D plays a pivotal role in immune system function. It acts as an immunomodulator, helping to regulate the immune response. A deficiency in vitamin D can compromise the feline immune system, potentially leading to increased susceptibility to infections and other diseases. Beyond its role in vitamin D transport, VDBP has a fascinating facet - its immunomodulatory properties. VDBP can interact with immune cells and various cytokines, potentially influencing the immune response in cats. This aspect of VDBP's function broadens its significance beyond vitamin D regulation and invites exploration into its broader impact on feline health and immune-related conditions. The regulation of VDBP synthesis adds yet another layer of complexity. It is influenced by several factors, including vitamin D status, hormones, and genetic factors. When vitamin D levels are low, the production of VDBP increases, enhancing vitamin D transport and utilization. Conversely, when vitamin D levels are elevated, VDBP levels may decrease, serving as a regulatory mechanism to prevent excessive vitamin D activity and potential toxicity.

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