Feline S100-A8 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-S100-A8-Ag01	Recombinant Feline S100-A8 protein	3090
GMP-FEL-S100-A8-Ab01	Anti-Feline S100-A8 mouse monoclonal antibody (mAb)	1953
GMP-FEL-S100-A8-Ab02	Anti-Feline S100-A8 mouse monoclonal antibody (mAb)	1953
GMP-FEL-S100-A8-Ab03	Anti-Feline S100-A8 human monoclonal antibody (mAb)	1953
GMP-FEL-S100-A8-Ab04	Anti-Feline S100-A8 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-S100-A8-Ag01
Product Name	Recombinant Feline S100-A8 protein
Target/Biomarker	Feline Calprotectin (S100-A8)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Calprotectin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in S100-A8 level test of animal Cat/Feline with intestinal inflammation.
Tag	His
Products description	Recombinant Feline S100-A8 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-S100-A8-Ab01, GMP-FEL-S100-A8-Ab02
Product Name	Anti-Feline S100-A8 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Calprotectin (S100-A8)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Calprotectin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies in S100-A8 level test of animal Cat/Feline with intestinal inflammation.
Tag	mFc
Products description	Anti-Feline S100-A8 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-S100-A8-Ab03, GMP-FEL-S100-A8-Ab04
Product Name	Anti-Feline S100-A8 human monoclonal antibody (mAb)
Target/Biomarker	Feline Calprotectin (S100-A8)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Calprotectin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies in S100-A8 level test of animal Cat/Feline with intestinal inflammation.
Tag	hFc
Products description	Anti-Feline S100-A8 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-S100-A8 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Feline S100-A8, or Calgranulin A, is an extraordinary player in the complex orchestra of feline immune responses. It belongs to the S100 protein family, renowned for its calcium-binding properties and its central role in shaping immune reactions in cats. Structurally, Feline S100-A8 exists as a dimeric protein, composed of two subunits, each featuring two calcium-binding EF-hand motifs. This structural intricacy enables it to finely tune its responses to calcium fluctuations, a feature that plays a vital role in its immune-regulating functions. While predominantly found within immune cells, particularly neutrophils and monocytes, Feline S100-A8 also has a presence in non-immune cells, underscoring its versatility in modulating immune responses and inflammation. In response to immune activation, Feline S100-A8 can transition from an intracellular to an extracellular role. It is secreted into the extracellular environment, where it assumes its multifaceted role as a mediator of immune responses. One of its primary functions is to promote the recruitment of immune cells to sites of infection or tissue damage. Feline S100-A8 acts as a powerful chemoattractant, guiding immune cells precisely to the locations where their activities are required. Furthermore, it contributes to the phagocytosis of pathogens, enhancing the ability of immune cells to engulf and eliminate microbial invaders. In addition to its proinflammatory functions, Feline S100-A8 also emerges as a key player in the processes of tissue repair and regeneration. It actively participates in the restoration of damaged tissues following immune responses, an essential step for the resolution of inflammation and the return to normal tissue function.

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