Feline Proinsulin antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-Proinsulin-Ag01	Recombinant Feline Proinsulin protein	3090
GMP-FEL-Proinsulin-Ab01	Anti-Feline Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-FEL-Proinsulin-Ab02	Anti-Feline Proinsulin mouse monoclonal antibody (mAb)	1953
GMP-FEL-Proinsulin-Ab03	Anti-Feline Proinsulin human monoclonal antibody (mAb)	1953
GMP-FEL-Proinsulin-Ab04	Anti-Feline Proinsulin human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-FEL-Proinsulin-Ag01
Product Name	Recombinant Feline Proinsulin protein
Target/Biomarker	Feline Proinsulin ()
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Proinsulin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in level test of animal Cat/Feline with type 2 diabetes.
Tag	His
Products description	Recombinant Feline Proinsulin protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-Proinsulin-Ab01, GMP-FEL-Proinsulin-Ab02
Product Name	Anti-Feline Proinsulin mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Proinsulin ()
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Cat/Feline with type 2 diabetes.
Tag	mFc
Products description	Anti-Feline Proinsulin mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-Proinsulin-Ab03, GMP-FEL-Proinsulin-Ab04
Product Name	Anti-Feline Proinsulin human monoclonal antibody (mAb)
Target/Biomarker	Feline Proinsulin ()
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Proinsulin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies in level test of animal Cat/Feline with type 2 diabetes.
Tag	hFc
Products description	Anti-Feline Proinsulin human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti- antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Feline Proinsulin, an intricate 86-amino acid peptide hormone, occupies a pivotal position in the multifaceted dance of insulin biosynthesis within cats. It is synthesized and secreted by the beta cells nestled within the pancreatic islets of Langerhans, marking the beginning of the remarkable journey toward the production of insulin, the master regulator of glucose metabolism in cats. The voyage of Cat Proinsulin commences with the synthesis of preproinsulin, a larger precursor molecule. This preproinsulin undergoes a profound metamorphosis, folding into proinsulin, a molecule comprising three distinct regions: the A chain, B chain, and a connecting peptide known as the C-peptide. Significantly, it is the presence of this C-peptide that sets proinsulin apart from mature insulin. During proinsulin processing, a meticulously choreographed sequence of enzymatic cleavage events takes place. Specific enzymes cleave the C-peptide from proinsulin, marking a critical transition in the process. This cleavage event transforms proinsulin into the active insulin molecule, which is then released into circulation, where it exerts its profound influence on glucose metabolism. The C-peptide, while often considered a byproduct of insulin processing, holds intrinsic value. It is not merely a structural element; it possesses physiological significance. Research suggests that the C-peptide may have independent actions on blood vessel health and other metabolic processes, making it a subject of scientific interest.

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