Feline LN antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-LN-Ag01	Recombinant Feline LN protein	3090
GMP-FEL-LN-Ab01	Anti-Feline LN mouse monoclonal antibody (mAb)	1953
GMP-FEL-LN-Ab02	Anti-Feline LN mouse monoclonal antibody (mAb)	1953
GMP-FEL-LN-Ab03	Anti-Feline LN human monoclonal antibody (mAb)	1953
GMP-FEL-LN-Ab04	Anti-Feline LN human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-LN-Ag01
Product Name	Recombinant Feline LN protein
Target/Biomarker	Feline Hyaluronic Acid Binding Protein (HABP)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Hyaluronic Acid Binding Protein antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in HABP level test of animal Cat/Feline with muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome.
Tag	His
Products description	Recombinant Feline LN protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-LN-Ab01, GMP-FEL-LN-Ab02
Product Name	Anti-Feline LN mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Hyaluronic Acid Binding Protein (HABP)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Hyaluronic Acid Binding Protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HABP antibodies in HABP level test of animal Cat/Feline with muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome.
Tag	mFc
Products description	Anti-Feline LN mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HABP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-LN-Ab03, GMP-FEL-LN-Ab04
Product Name	Anti-Feline LN human monoclonal antibody (mAb)
Target/Biomarker	Feline Hyaluronic Acid Binding Protein (HABP)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Hyaluronic Acid Binding Protein antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HABP antibodies in HABP level test of animal Cat/Feline with muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome.
Tag	hFc
Products description	Anti-Feline LN human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-HABP antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

The Feline Lymph Node (fLN) emerges as a cornerstone of the feline immune system, diligently carrying out immune surveillance and orchestrating complex immune responses to safeguard a cat's health. Positioned strategically in various anatomical regions, the fLN serves as a sentinel, tirelessly monitoring the body's interstitial fluid, capturing antigens, and coordinating immune defenses. Structurally, the fLN is an encapsulated organ, enclosed by a fibrous tissue known as the capsule. This capsule houses an intricate network of lymphatic sinuses and nodules where immune cells reside and interact. Within these microenvironments, immune cells are stationed, primed to detect and respond to potential threats. Among these immune cells, lymphocytes, the primary players of adaptive immunity, abound. T cells and B cells, distinct lymphocyte subsets, collaborate to recognize and target specific antigens, while macrophages act as the body's professional scavengers, clearing cellular debris and engulfing foreign invaders. When antigens enter the lymphatic fluid, either through infection or other means, a series of events unfolds within the fLN. Antigen-presenting cells, including dendritic cells, encounter these antigens and capture them. They then migrate to the fLN, where they present the antigens to T cells. This presentation serves as a call to arms, activating T cells that recognize the specific antigen. B cells within the fLN also play a crucial role by producing antibodies that can neutralize invaders. The fLN, in essence, functions as a training ground for immune cells. It is where naïve lymphocytes are exposed to antigens, learn to differentiate self from non-self, and develop memory responses. This training is critical for the cat's ability to mount swift and specific immune defenses upon subsequent encounters with the same antigens.

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