Feline LN antibody and antigen (recombinant protein)

Diagnostic anti-Feline LN antibodies pairs and antigen for animal health (animal Cat/Feline muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-FEL-LN-Ag01Feline LN$3090.00
GMP-FEL-LN-Ab01Anti-Feline LN mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-LN-Ab02Anti-Feline LN mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-LN-Ab03Anti-Feline LN human monoclonal antibody (mAb)$3090.00
GMP-FEL-LN-Ab04Anti-Feline LN human monoclonal antibody (mAb)$3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-FEL-LN-Ag01
Product NameFeline LN
Target/BiomarkerFeline LN
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Feline LN antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in LN level test of animal Cat/Feline with muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome.
TagHis
Reconized/Reactive SpecicsFeline LN
Product descriptionRecombinant Feline LN protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-LN-Ab01,GMP-FEL-LN-Ab02
Target/BiomarkerFeline LN
Product NameAnti-Feline LN mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Feline LN antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline LN antibodies in Feline LN level test of animal Cat/Feline with muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome.
Product descriptionAnti-Feline LN mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline LN antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-LN-Ab03,GMP-FEL-LN-Ab04
Target/BiomarkerFeline LN
Product NameAnti-Feline LN human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Feline LN antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline LN antibodies in Feline LN level test of animal Cat/Feline with muscular dystrophy, lethal skin blistering disease (junctional epidermolysis bullosa) and nephrotic syndrome.
Product descriptionAnti-Feline LN mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    The Feline Lymph Node (fLN) emerges as a cornerstone of the feline immune system, diligently carrying out immune surveillance and orchestrating complex immune responses to safeguard a cat's health. Positioned strategically in various anatomical regions, the fLN serves as a sentinel, tirelessly monitoring the body's interstitial fluid, capturing antigens, and coordinating immune defenses.

    Structurally, the fLN is an encapsulated organ, enclosed by a fibrous tissue known as the capsule. This capsule houses an intricate network of lymphatic sinuses and nodules where immune cells reside and interact. Within these microenvironments, immune cells are stationed, primed to detect and respond to potential threats. Among these immune cells, lymphocytes, the primary players of adaptive immunity, abound. T cells and B cells, distinct lymphocyte subsets, collaborate to recognize and target specific antigens, while macrophages act as the body's professional scavengers, clearing cellular debris and engulfing foreign invaders.

    When antigens enter the lymphatic fluid, either through infection or other means, a series of events unfolds within the fLN. Antigen-presenting cells, including dendritic cells, encounter these antigens and capture them. They then migrate to the fLN, where they present the antigens to T cells. This presentation serves as a call to arms, activating T cells that recognize the specific antigen. B cells within the fLN also play a crucial role by producing antibodies that can neutralize invaders.

    The fLN, in essence, functions as a training ground for immune cells. It is where naïve lymphocytes are exposed to antigens, learn to differentiate self from non-self, and develop memory responses. This training is critical for the cat's ability to mount swift and specific immune defenses upon subsequent encounters with the same antigens.



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