Feline FIB antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-FIB-Ag01	Recombinant Feline FIB protein	3090
GMP-FEL-FIB-Ab01	Anti-Feline FIB mouse monoclonal antibody (mAb)	1953
GMP-FEL-FIB-Ab02	Anti-Feline FIB mouse monoclonal antibody (mAb)	1953
GMP-FEL-FIB-Ab03	Anti-Feline FIB human monoclonal antibody (mAb)	1953
GMP-FEL-FIB-Ab04	Anti-Feline FIB human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-FIB-Ag01
Product Name	Recombinant Feline FIB protein
Target/Biomarker	Feline Fibrinogen (FIB)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Fibrinogen antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in FIB level test of animal Cat/Feline with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	His
Products description	Recombinant Feline FIB protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-FIB-Ab01, GMP-FEL-FIB-Ab02
Product Name	Anti-Feline FIB mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Fibrinogen (FIB)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Fibrinogen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies in FIB level test of animal Cat/Feline with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	mFc
Products description	Anti-Feline FIB mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-FIB-Ab03, GMP-FEL-FIB-Ab04
Product Name	Anti-Feline FIB human monoclonal antibody (mAb)
Target/Biomarker	Feline Fibrinogen (FIB)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Fibrinogen antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies in FIB level test of animal Cat/Feline with congenital afibrinogenemia, congenital hypofibrinogenemia, fibrinogen storage disease, congenital dysfibrinogenemia, hereditary fibrinogen Aα-Chain amyloidosis, acquired dysfibrinogenemia, congenital hypodysfibrinogenemia, and cryofibrinogenemia.
Tag	hFc
Products description	Anti-Feline FIB human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-FIB antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Feline Fibrinogen, a remarkable component of the feline circulatory system, warrants a closer examination. Structurally, it is a glycoprotein of notable complexity, consisting of three intertwining polypeptide chains: alpha, beta, and gamma. These chains unite to form a large hexameric molecule with a molecular mass of approximately 340 kDa. The synthesis of Feline Fibrinogen predominantly occurs in the hepatocytes of the liver, after which it enters the bloodstream, poised for its crucial role in hemostasis. At the core of Feline Fibrinogen's function lies its conversion to fibrin, a process that serves as the linchpin of blood clot formation. In response to vascular injury or other hemostatic triggers, the enzyme thrombin catalyzes the cleavage of FIB's alpha and beta chains. This enzymatic reaction liberates fibrin, which undergoes rapid polymerization, creating long strands. These strands intertwine to form a meshwork, the scaffold of a blood clot that effectively halts bleeding. The dynamic nature of Feline Fibrinogen makes it a versatile and responsive biomarker. During episodes of inflammation, infection, or tissue injury, its synthesis escalates as part of the acute-phase response. This heightened production equips the body with an enhanced capacity to form blood clots at sites of injury, reinforcing the physiological defense mechanisms against potential threats.

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