Feline Dig antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-Dig-Ag01	Recombinant Feline Dig protein	3090
GMP-FEL-Dig-Ab01	Anti-Feline Dig mouse monoclonal antibody (mAb)	1953
GMP-FEL-Dig-Ab02	Anti-Feline Dig mouse monoclonal antibody (mAb)	1953
GMP-FEL-Dig-Ab03	Anti-Feline Dig human monoclonal antibody (mAb)	1953
GMP-FEL-Dig-Ab04	Anti-Feline Dig human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-Dig-Ag01
Product Name	Recombinant Feline Dig protein
Target/Biomarker	Feline Digoxigenin (Dig)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Digoxigenin antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Dig level test of animal Cat/Feline with N/A.
Tag	His
Products description	Recombinant Feline Dig protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-Dig-Ab01, GMP-FEL-Dig-Ab02
Product Name	Anti-Feline Dig mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Digoxigenin (Dig)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline Digoxigenin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies in Dig level test of animal Cat/Feline with N/A.
Tag	mFc
Products description	Anti-Feline Dig mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-Dig-Ab03, GMP-FEL-Dig-Ab04
Product Name	Anti-Feline Dig human monoclonal antibody (mAb)
Target/Biomarker	Feline Digoxigenin (Dig)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline Digoxigenin antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies in Dig level test of animal Cat/Feline with N/A.
Tag	hFc
Products description	Anti-Feline Dig human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Dig antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Feline Dig, or digoxin in cats, is a biomarker of paramount importance in veterinary cardiology. It refers to the measurement of digoxin levels in the bloodstream of domestic cats (Felis catus). Digoxin is a cardiac glycoside medication that has been used for decades to treat a variety of heart conditions in both humans and feline patients. Digoxin exerts its therapeutic effects by inhibiting the sodium-potassium pump in cardiac muscle cells. This inhibition leads to an increase in intracellular calcium levels, which, in turn, enhances the force of cardiac muscle contraction while reducing heart rate. In cats with heart conditions such as congestive heart failure (CHF) and specific arrhythmias, digoxin is employed to improve cardiac function, alleviate symptoms, and extend life expectancy. The measurement of Feline Dig serves several crucial purposes. Firstly, it allows veterinarians to ascertain the concentration of digoxin in a cat's bloodstream, which is essential for maintaining the drug within the narrow therapeutic range. Cats, like humans, exhibit individual variability in drug metabolism and sensitivity, making precise dosing a challenge. Feline Dig monitoring ensures that the cat receives an appropriate dosage to achieve therapeutic effects without risking toxicity. Furthermore, Feline Dig measurement aids in assessing the cat's response to digoxin therapy over time. Cardiac conditions are dynamic, and the optimal dosage of digoxin may need adjustments as the cat's condition evolves. By regularly monitoring Feline Dig levels, veterinarians can tailor treatment plans to suit the individual needs of the patient, optimizing both efficacy and safety.

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