Feline ACTH antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-FEL-ACTH-Ag01	Recombinant Feline ACTH protein	3090
GMP-FEL-ACTH-Ab01	Anti-Feline ACTH mouse monoclonal antibody (mAb)	1953
GMP-FEL-ACTH-Ab02	Anti-Feline ACTH mouse monoclonal antibody (mAb)	1953
GMP-FEL-ACTH-Ab03	Anti-Feline ACTH human monoclonal antibody (mAb)	1953
GMP-FEL-ACTH-Ab04	Anti-Feline ACTH human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-FEL-ACTH-Ag01
Product Name	Recombinant Feline ACTH protein
Target/Biomarker	Feline adrenocorticotropic hormone (ACTH)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline adrenocorticotropic hormone antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ACTH level test of animal Cat/Feline with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	His
Products description	Recombinant Feline ACTH protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-ACTH-Ab01, GMP-FEL-ACTH-Ab02
Product Name	Anti-Feline ACTH mouse monoclonal antibody (mAb)
Target/Biomarker	Feline adrenocorticotropic hormone (ACTH)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline adrenocorticotropic hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies in ACTH level test of animal Cat/Feline with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	mFc
Products description	Anti-Feline ACTH mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-ACTH-Ab03, GMP-FEL-ACTH-Ab04
Product Name	Anti-Feline ACTH human monoclonal antibody (mAb)
Target/Biomarker	Feline adrenocorticotropic hormone (ACTH)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Feline adrenocorticotropic hormone antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies in ACTH level test of animal Cat/Feline with pituitary or adrenal malfunction, pituitary tumor, adrenal tumor, lung tumor.
Tag	hFc
Products description	Anti-Feline ACTH human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-ACTH antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Adrenocorticotropic Hormone (ACTH) stands as a pivotal biomarker in the intricate web of feline endocrinology, orchestrating the cat's response to stressors and maintaining hormonal equilibrium. Structurally, ACTH is a 39-amino acid peptide hormone synthesized and secreted by the anterior pituitary gland. It belongs to the melanocortin family, a diverse group of hormones with multifaceted physiological roles. The primary mission of ACTH lies in its governance of the adrenal glands, specifically the adrenal cortex. When the feline body perceives stress or detects alterations in its internal milieu, the hypothalamus responds by releasing corticotropin-releasing hormone (CRH). CRH, in turn, kindles the anterior pituitary gland to unleash ACTH into the bloodstream. In its journey through circulation, ACTH reaches the adrenal cortex, where it binds to specific receptors adorning the surface of adrenal cells. This binding event ignites a cascade of intracellular processes culminating in the synthesis and release of cortisol, a corticosteroid hormone. Often referred to as the "stress hormone," cortisol exerts far-reaching effects on feline physiology. Cortisol wields the power to modulate metabolism, influence immune function, and dictate the feline response to stressors. It elevates blood glucose levels, tames immune responses, and orchestrates anti-inflammatory actions. Furthermore, cortisol influences protein and fat metabolism, maintains electrolyte balance, and bears influence on cardiovascular function.

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