Equine p-tau422 antibody and antigen (recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-EQU-p-tau422-Ag01	Recombinant Equine p-tau422 protein	3090
GMP-EQU-p-tau422-Ab01	Anti-Equine p-tau422 mouse monoclonal antibody (mAb)	1953
GMP-EQU-p-tau422-Ab02	Anti-Equine p-tau422 mouse monoclonal antibody (mAb)	1953
GMP-EQU-p-tau422-Ab03	Anti-Equine p-tau422 human monoclonal antibody (mAb)	1953
GMP-EQU-p-tau422-Ab04	Anti-Equine p-tau422 human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-EQU-p-tau422-Ag01
Product Name	Recombinant Equine p-tau422 protein
Target/Biomarker	Equine Phospho-tau422 (p-tau422)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Equine Phospho-tau422 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau422 level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Equine p-tau422 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-p-tau422-Ab01, GMP-EQU-p-tau422-Ab02
Product Name	Anti-Equine p-tau422 mouse monoclonal antibody (mAb)
Target/Biomarker	Equine Phospho-tau422 (p-tau422)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Equine Phospho-tau422 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau422 antibodies in p-tau422 level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Equine p-tau422 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau422 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-EQU-p-tau422-Ab03, GMP-EQU-p-tau422-Ab04
Product Name	Anti-Equine p-tau422 human monoclonal antibody (mAb)
Target/Biomarker	Equine Phospho-tau422 (p-tau422)
Expression platform	CHO
Isotypes	Human IgG1
Bioactivity validation	Recombinant Equine Phospho-tau422 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau422 antibodies in p-tau422 level test of animal Equine/Horse with Alzheimer Disease(AD).
Tag	hFc
Products description	Anti-Equine p-tau422 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-p-tau422 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Associated products

Target/Biomarker information

Equine p-tau422 represents a specific subset of tau proteins intricately involved in the neurological landscape of horses. These phosphorylated tau variants are primarily localized within the central nervous system (CNS) of horses, where they play a vital role in maintaining the structural stability of neuronal microtubules. Structurally, it shares genetic and functional homology with its counterparts in other species, including humans. Under normal circumstances, tau proteins like p-tau422 bind to microtubules and aid in their assembly, ensuring proper neuronal function, axonal transport, and synaptic communication. However, in the context of neurodegenerative conditions observed in horses, tau proteins like p-tau422 undergo abnormal phosphorylation. This post-translational modification results in tau proteins adopting atypical conformations, rendering them prone to aggregation. The aggregation of tau proteins culminates in the formation of neurofibrillary tangles within neurons. These tangles disrupt axonal transport, impair synaptic function, and eventually result in neuronal dysfunction and death. The presence of elevated levels of p-tau422 is indicative of these pathological tau modifications and the potential development of neurodegenerative diseases in horses.

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